{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:31Z","timestamp":1791174691025,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000019","name":"Crohn\u2019s and Colitis Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003179","name":"Alberta Heritage Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomedicine and Biotechnology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To compare infection with the tapeworm,<jats:italic>Hymenolepis diminuta<\/jats:italic>, with steroid (dexamethasone) administration in the inhibition of dinitrobenzene sulfonic acid- (DNBS-) induced colitis in mice.<jats:italic>Procedures<\/jats:italic>. Mice were treated with DNBS<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>\u00b1<\/mml:mo><\/mml:math>infected with<jats:italic>H. diminuta<\/jats:italic>or treated with daily dexamethasone (2\u2009mg\/Kg, ip.) and were assessed 72 hours post-DNBS by the calculation of disease activity and histological damage scores, and spleen cell cytokine production.<jats:italic>Results<\/jats:italic>.<jats:italic>H. diminuta<\/jats:italic>-infected mice showed increased IL-4 and IL-10 production by spleen cells compared to other groups and were protected from DNBS-induced colitis. In contrast, there was little benefit of dexamethasone in the treatment of colitis. Collagen deposition in the colon was not different between the groups.<jats:italic>Conclusions<\/jats:italic>.<jats:italic>H. diminuta<\/jats:italic>was superior to dexamethasone in the prevention of DNBS-induced colitis and did not result in additional side effects (i.e., collagen deposition). Comparisons with current therapeutics and long-term followup to studies are essential if \u201chelminth therapy\u201d is to become a viable treatment for specific inflammatory diseases in the gut or other tissues.<\/jats:p>","DOI":"10.1155\/2010\/384523","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T07:47:44Z","timestamp":1259653664000},"page":"1-7","source":"Crossref","is-referenced-by-count":38,"title":["Infection with<i>Hymenolepis diminuta<\/i>Is More Effective than Daily Corticosteroids in Blocking Chemically Induced Colitis in Mice"],"prefix":"10.1155","volume":"2010","author":[{"given":"Alexandra","family":"Melon","sequence":"first","affiliation":[{"name":"Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Phoebe & Joan Snyder Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, AB, Canada T2N 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