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Here, we have reviewed the literature for reports of small-, medium-, and large-vessel vasculitis occurring in SSc. Amongst 88 reported cases of vasculitis in SSc, patients with ANCA-associated vasculitis appear to present a unique subclass in that they combined typical features of SSc with the renal manifestation of ANCA-associated glomerulonephritis. Other vasculitic syndromes, including large-vessel vasculitis, Behcet's disease, cryoglobulinemia, and polyarteritis nodosa, are rarely encountered in SSc patients. ANCA-associated vasculitis needs to be considered as a differential diagnosis in SSc patients presenting with renal insufficiency, as renal manifestations may result from distinct disease processes and require appropriate diagnostic testing and treatment.<\/jats:p>","DOI":"10.1155\/2010\/385938","type":"journal-article","created":{"date-parts":[[2010,9,30]],"date-time":"2010-09-30T18:36:54Z","timestamp":1285871814000},"page":"1-9","source":"Crossref","is-referenced-by-count":27,"title":["Vasculitis in Systemic Sclerosis"],"prefix":"10.1155","volume":"2010","author":[{"given":"Lily","family":"Kao","sequence":"first","affiliation":[{"name":"Division of Immunology and Rheumatology, School of Medicine, Stanford University, Stanford, 1000 Welch Road, Suite #203, Palo Alto, CA 94304, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Weyand","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, School of Medicine, 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