{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:38:07Z","timestamp":1773661087603,"version":"3.50.1"},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Health, Czech Republic","award":["NS\/9743-4"],"award-info":[{"award-number":["NS\/9743-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomedicine and Biotechnology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Myasthenia gravis (MG) is a neuromuscular disorder leading to fluctuating muscle weakness and fatigue. Rarely, long-term stabilization is not possible through the use of thymectomy or any known drug therapy. We present our experience with extracorporeal immunoglobulin (Ig) elimination by immunoadsorption (adsorbers with human Ig antibodies). Acetylcholine receptor antibodies (AChRAs) were measured during long-term monitoring (4.7<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>\u00b1<\/mml:mo><\/mml:math>2.9 years; range 1.1\u20138.0). A total of 474 samples (232 pairs) were analyzed, and a drop in AChRA levels was observed (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.025<\/mml:mn><\/mml:mrow><\/mml:math>). The clinical status of patients improved and stabilized. Roughly 6.8% of patients experienced clinically irrelevant side effects. The method of Ig elimination by extracorporeal immunoadsorption (IA) is a clinical application of the recent biotechnological advances. It offers an effective and safe therapy for severe MG even when the disease is resistant to standard therapy.<\/jats:p>","DOI":"10.1155\/2010\/419520","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T15:30:24Z","timestamp":1268667024000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Extracorporeal Immunoglobulin Elimination for the Treatment of Severe Myasthenia Gravis"],"prefix":"10.1155","volume":"2010","author":[{"given":"M.","family":"Blaha","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine, Hematology, Faculty of Medicine and Teaching Hospital, Charles University, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pit'ha","sequence":"additional","affiliation":[{"name":"Department of Neurology, 1st Faculty of Medicine and General Teaching Hospital, Charles University, 120 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Blaha","sequence":"additional","affiliation":[{"name":"Department of Metabolic Care and Gerontology, Faculty of Medicine and Teaching Hospital, Charles University, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lanska","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Hematology, Faculty of Medicine and Teaching Hospital, Charles University, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Maly","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Hematology, Faculty of Medicine and Teaching Hospital, Charles University, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology, Faculty of Medicine and Teaching Hospital, Charles University, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Langrova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine and Teaching Hospital, Charles University, 500 05 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29894"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1517\/14656560902950619"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2008.08.011"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-008-0579-7"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0955-3886(94)90173-2"},{"issue":"3","key":"7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/mus.21493","volume":"41","year":"2010","journal-title":"Muscle & Nerve"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1046\/j.1526-0968.2003.00008.x","volume":"7","year":"2003","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2009.00684.x"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.transci.2009.05.013","volume":"41","year":"2009","journal-title":"Transfusion and Apheresis Science"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(00)00126-0"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00374.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/275287"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/289068"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/369129"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/76087"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/92385"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70063-8"},{"key":"19","year":"2008"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21195"}],"container-title":["Journal of Biomedicine and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2010\/419520.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2010\/419520.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2010\/419520.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T06:07:27Z","timestamp":1497852447000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2010\/419520\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":19,"alternative-id":["419520","419520"],"URL":"https:\/\/doi.org\/10.1155\/2010\/419520","relation":{},"ISSN":["1110-7243","1110-7251"],"issn-type":[{"value":"1110-7243","type":"print"},{"value":"1110-7251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}