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Anti-TNF- therapies have been provided clinical benefit to many patients and introduced for treating moderate to severe rheumatoid arthritis, Crohn's disease, and other chronic inflammatory disorders. However, their use also is accompanied by new or aggravated forms of autoimmunity, such as formation of autoantibodies, including antinuclear antibodies (ANAs), antidouble-stranded DNA (dsDNA) antibodies, and anticardiolipin antibodies (ACL). Systemic lupus erythematosus (SLE) is a disease with autoimmune disturbance and inflammatory damage. The role of TNF- in human SLE is controversial. Here we review the role of TNF- in the pathophysiological processes of SLE and the likely effects of blocking TNF- in treatment of SLE.<\/jats:p>","DOI":"10.1155\/2010\/465898","type":"journal-article","created":{"date-parts":[[2010,6,22]],"date-time":"2010-06-22T14:35:40Z","timestamp":1277217340000},"page":"1-8","source":"Crossref","is-referenced-by-count":62,"title":["Anti-TNF-\u03b1 Therapies in Systemic Lupus Erythematosus"],"prefix":"10.1155","volume":"2010","author":[{"given":"Lang-Jing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"},{"name":"Department of Rheumatology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, 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