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Our strategy was to combine all available information from previous literature, in order to provide a complete structured review on the prokinetic properties of exogenous ghrelin and its potential use for treatment of\nvarious GI dysmotility ailments. We classified the literature into two major groups, depending on whether studies were done in health\nor in disease. We sub-classified the studies into stomach, small intestinal and colon studies, and broke them down further into\nstudies done in vitro, in vivo (animals) and in humans. Further more, the reviewed studies were presented in a chronological order\nto guide the readers across the scientific advances in the field. The review shows evidences that ghrelin and its (receptor)\nagonists possess a strong prokinetic potential to serve in the treatment of diabetic, neurogenic or idiopathic gastroparesis and\npossibly, chemotherapy-associated dyspepsia, postoperative, septic or post-burn ileus, opiate-induced bowel dysfunction and chronic\nidiopathic constipation. Further research is necessary to close the gap in knowledge about the effect of ghrelin on the human\nintestines in health and disease.<\/jats:p>","DOI":"10.1155\/2010\/493614","type":"journal-article","created":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T15:30:51Z","timestamp":1265815851000},"page":"1-11","source":"Crossref","is-referenced-by-count":12,"title":["The Prokinetic Face of Ghrelin"],"prefix":"10.1155","volume":"2010","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3848-3055","authenticated-orcid":true,"given":"Hanaa S.","family":"Sallam","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterolog, University of Texas Medical Branch, Galveston, TX 77550, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiande D. 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