{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:11:53Z","timestamp":1791389513018,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T00:00:00Z","timestamp":1277856000000},"content-version":"vor","delay-in-days":180,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic> Interleukin\u20104 (IL\u20104), a Th<jats:sub>2<\/jats:sub> cytokine, can stimulate immunoglobulin E (IgE) transcription. No previous studies evaluated the genetic mechanisms in nonatopic AA patients with elevated serum IgE. <jats:italic>Objective.<\/jats:italic> To compare serum IL\u20104 and total IgE levels between Egyptian nonatopic AA patients and healthy subjects and to investigate a possible relation to HLA\u2010DRB1 alleles. <jats:italic>Results.<\/jats:italic> Serum IL\u20104 and total IgE were measured by ELISA in 40 controls and 54 nonatopic AA patients. Patients\u2032 HLA\u2010DRB1 typing by sequence specific oligonucleotide probe technique was compared to normal Egyptian population. We found significantly elevated serum IL\u20104 and total IgE in AA patients (particularly alopecia universalis, AU, and chronic patients) (<jats:italic>P<\/jats:italic> &lt; .01). HLA\u2010DRB1*11 is a general susceptibility\/chronicity allele. DRB1*13 is a protective allele. DRB1*01 and DRB1*07 are linked to chronicity. Localized AA showed decreased DRB1*03 and DRB1*07. Extensive forms showed increased DRB1*08 and decreased DRB1*04. Elevated IL4 and IgE were observed in patients with DRB1*07 and DRB1*11 not DRB1*04. <jats:italic>Conclusion.<\/jats:italic> Serum IL\u20104 and IgE are elevated in nonatopic AA patients, particularly AU and chronic disease. Relevant susceptibility, chronicity, and severity HLADRB1 alleles may have a role in determining type, magnitude, and duration of immune response in AA favouring increased IL4 and IgE.<\/jats:p>","DOI":"10.1155\/2010\/503587","type":"journal-article","created":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T15:14:19Z","timestamp":1277910859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Serum Interleukin\u20104 and Total Immunoglobulin E in Nonatopic Alopecia Areata Patients and HLA\u2010DRB1 Typing"],"prefix":"10.1155","volume":"2010","author":[{"given":"Enas A. 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