{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:47:01Z","timestamp":1767422821289,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG029124-03"],"award-info":[{"award-number":["R01 AG029124-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Anemia of inflammation (AI), also known as anemia of chronic inflammation or anemia of chronic disease was described over 50 years ago as anemia in association with clinically overt inflammatory disease, and the findings of low plasma iron, decreased bone marrow sideroblasts and increased reticuloendothelial iron. Pathogenic features underlying AI include a mild shortening of red cell survival, impaired erythropoietin production, blunted responsiveness of the marrow to erythropoietin, and impaired iron metabolism mediated by inflammatory cytokines and the iron regulatory peptide, hepcidin. Despite marked recent advances in understanding AI, gaps remain, including understanding of the pathogenesis of AI associated with \u201cnoninflammatory\u201d or mildly inflammatory diseases, the challenge of excluding iron deficiency anemia in the context of concomitant inflammation, and understanding more precisely the contributory role of hepcidin in the development of AI in human inflammatory diseases.<\/jats:p>","DOI":"10.1155\/2010\/508739","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T00:30:25Z","timestamp":1269477025000},"page":"1-5","source":"Crossref","is-referenced-by-count":18,"title":["Unexplained Aspects of Anemia of Inflammation"],"prefix":"10.1155","volume":"2010","author":[{"given":"Elizabeth A.","family":"Price","sequence":"first","affiliation":[{"name":"Department of Medicine (Hematology), Stanford University, Stanford, CA 94305-3434, USA"},{"name":"Division of Hematology, Stanford Comprehensive Cancer Center, 875 Blake Wilbur Drive, Stanford, CA 94305, USA"}]},{"given":"Stanley L.","family":"Schrier","sequence":"additional","affiliation":[{"name":"Department of Medicine (Hematology), Stanford University, Stanford, CA 94305-3434, USA"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"351","volume":"3","year":"1966","journal-title":"Seminars in Hematology"},{"issue":"1","key":"2","first-page":"7","volume":"70","year":"1999","journal-title":"International Journal of Hematology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041809"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.08.006"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0136"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1610"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092205"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-028787"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1159"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027631"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3235"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051755"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01357.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(89)80396-1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1812"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90112-3"},{"issue":"6","key":"19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/gerona\/61.6.575","volume":"61","year":"2006","journal-title":"Journals of Gerontology A"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.06.039"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06502.x"},{"issue":"1","key":"22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0002-9343(67)90013-7","volume":"42","year":"1967","journal-title":"The American Journal of Medicine"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000180"},{"issue":"4","key":"24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1182\/blood.V33.4.564.564","volume":"33","year":"1969","journal-title":"Blood"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/2281204a0"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi388"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.034"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1373\/49.10.1573"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195651"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818103b9"},{"issue":"4","key":"31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0272-6386(97)90339-5","volume":"29","year":"1997","journal-title":"American Journal of Kidney Diseases"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000071514.36428.61"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.21"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/nm1629"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-178095"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02182.x"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4043"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05931108"}],"container-title":["Advances in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ah\/2010\/508739.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ah\/2010\/508739.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ah\/2010\/508739.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T08:02:49Z","timestamp":1591171369000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ah\/2010\/508739\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":38,"alternative-id":["508739","508739"],"URL":"https:\/\/doi.org\/10.1155\/2010\/508739","relation":{},"ISSN":["1687-9104","1687-9112"],"issn-type":[{"type":"print","value":"1687-9104"},{"type":"electronic","value":"1687-9112"}],"subject":[],"published":{"date-parts":[[2010]]}}}