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The aims were to further elucidate if an accumulation of sensitising substances or impaired oxygenation is evident in painful muscles during RW. Females with TM (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>14<\/mml:mn><\/mml:math>) were studied during rest, 30 minutes RW and 60 minutes recovery. Microdialysate samples were obtained to determine changes in intramuscular microdialysate (IMMD) [glutamate], [PG<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>E<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msub><\/mml:math>], [lactate], and [pyruvate] (i.e., [concentration]) relative to work. Muscle oxygenation (%St<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>O<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msub><\/mml:math>) was assessed using near-infrared spectroscopy. During work, all investigated substances, except PG<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>E<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msub><\/mml:math>, increased significantly: [glutamate] (54%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.0001<\/mml:mn><\/mml:math>), [lactate] (26%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.005<\/mml:mn><\/mml:math>), [pyruvate] (19%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.0001<\/mml:mn><\/mml:math>), while the %St<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>O<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msub><\/mml:math>decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.05<\/mml:mn><\/mml:math>). During recovery [PG<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>E<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msub><\/mml:math>] decreased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.005<\/mml:mn><\/mml:math>), [lactate] remained increased (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:math>), [pyruvate] increased progressively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.0001<\/mml:mn><\/mml:math>), and %St<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:msub><mml:mtext>O<\/mml:mtext><mml:mn>2<\/mml:mn><\/mml:msub><\/mml:math>had returned to baseline. Changes in substance concentrations and oxygenation in response to work indicate normal increase in metabolism but no ongoing inflammation in subjects with TM.<\/jats:p>","DOI":"10.1155\/2010\/513803","type":"journal-article","created":{"date-parts":[[2010,6,13]],"date-time":"2010-06-13T14:34:56Z","timestamp":1276439696000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Combining Microdialysis and Near-Infrared Spectroscopy for Studying Effects of Low-Load Repetitive Work on the Intramuscular Chemistry in Trapezius Myalgia"],"prefix":"10.1155","volume":"2010","author":[{"given":"Gerd M.","family":"Flodgren","sequence":"first","affiliation":[{"name":"Centre for Musculoskeletal Research, University of G\u00e4vle, P.O. 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