{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:49:09Z","timestamp":1790480949272,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100012592","name":"Foundation for Research, Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012592","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>DNA samples from 339 Crohn's disease (CD) and 407 randomly selected controls from the Auckland (New Zealand) IBD project, were genotyped for five common single nucleotide polymorphisms in<jats:italic>IL-23R<\/jats:italic>(rs11805303, rs7517847, rs1343151, rs11209026, and rs10889677) and two in<jats:italic>IL-12B<\/jats:italic>(rs1363670 and rs6887695). While the<jats:italic>IL-12B<\/jats:italic>variants did not show an overall association and other<jats:italic>IL23R<\/jats:italic>variants led to minor changes in the risk of CD, rs1343151 and\/or rs7517847 variants in the<jats:italic>IL-23R<\/jats:italic>gene strongly reduced the risk of developing CD at both allelic and genotype levels. A significantly decreased risk of first diagnosis of childhood CD was observed in individuals carrying the A allele of rs1343151, or between 17\u201340\u2009y in individuals carrying the G allele in rs7517847 of<jats:italic>IL-23R<\/jats:italic>. A significantly decreased risk of ileocolonic or structuring disease was observed in individuals carrying the A allele in either rs11209026 or rs1343151, or the G allele in rs7517847 of<jats:italic>IL-23R<\/jats:italic>, and when such individuals did develop the disease, they were unlikely to require a bowel resection. Certain haplotypes very strongly modified risk. There was evidence for interactions of<jats:italic>IL-23R<\/jats:italic>variants with the<jats:italic>NOD2<\/jats:italic>wild-type (d\/d) genotype. Down-regulating the function of the<jats:italic>IL-23R<\/jats:italic>gene may decrease CD risk in the normal population.<\/jats:p>","DOI":"10.1155\/2010\/539461","type":"journal-article","created":{"date-parts":[[2010,12,27]],"date-time":"2010-12-27T19:37:35Z","timestamp":1293478655000},"page":"1-12","source":"Crossref","is-referenced-by-count":28,"title":["<i>IL23R<\/i>and<i>IL12B<\/i>SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population"],"prefix":"10.1155","volume":"2010","author":[{"given":"Lynnette R.","family":"Ferguson","sequence":"first","affiliation":[{"name":"Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dug Yeo","family":"Han","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Nutrigenomics, New Zealand"},{"name":"Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Huebner","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Jiun","family":"Lam","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angharad R.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, 1142, New Zealand"},{"name":"Nutrigenomics, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mib.0000231572.88806.b9"},{"issue":"1283","key":"2","first-page":"19","volume":"121","year":"2008","journal-title":"New Zealand Medical Journal"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1586\/eci.10.43"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136668"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135245"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20126"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.122069"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01525.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.163667"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.10.032"},{"issue":"11","key":"11","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.4049\/jimmunol.168.11.5699","volume":"168","year":"2002","journal-title":"Journal of Immunology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0264-4"},{"issue":"170","key":"13","first-page":"2","volume":"24","year":"1989","journal-title":"Scandinavian Journal of Gastroenterology, Supplement"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1054\/modi.2000.19574"},{"key":"15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/3-540-45713-5_4","volume":"77","year":"2002","journal-title":"Advances in Biochemical Engineering\/Biotechnology"},{"key":"16","first-page":"241","volume":"212","year":"2003","journal-title":"Methods in Molecular Biology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.2307\/2533494"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1086\/429864"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","volume":"5","year":"1996","journal-title":"Journal of Computational and Graphical Statistics"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/ng1954"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/nature05911"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2370.2003.00411.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030058"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01660.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.04.024"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20372"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318141a1de"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-007-0156-z"},{"issue":"3","key":"29","first-page":"823","volume":"150","year":"1997","journal-title":"American Journal of Pathology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.495"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900401"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.5.1281"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.135053"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701255"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000041"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1080\/08916930802422265"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.233"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21404"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25308"},{"issue":"5","key":"40","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.4049\/jimmunol.177.5.2760","volume":"177","year":"2006","journal-title":"Journal of Immunology"},{"issue":"12","key":"41","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.4049\/jimmunol.178.12.8138","volume":"178","year":"2007","journal-title":"Journal of Immunology"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2010.01.001"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2010.01.020"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2010\/539461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2010\/539461.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2010\/539461.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T04:19:32Z","timestamp":1740802772000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/grp\/2010\/539461\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":43,"alternative-id":["539461","539461"],"URL":"https:\/\/doi.org\/10.1155\/2010\/539461","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}