{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:12:30Z","timestamp":1780963950944,"version":"3.54.1"},"reference-count":15,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T00:00:00Z","timestamp":1292284800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[2010,12,14]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. For M1 pancreatic adenocarcinomas pancreatic resection is usually not indicated. However, in highly selected patients synchronous metastasectomy may be appropriate together with pancreatic resection when operative morbidity is low.\n<jats:italic>Materials and Methods<\/jats:italic>. From January 1, 2004 to December, 2007 a total of 20 patients with pancreatic malignancies were retrospectively evaluated who underwent pancreatic surgery with synchronous resection of hepatic, adjacent organ, or peritoneal metastases for proven UICC stage IV periampullary cancer of the pancreas. Perioperative as well as clinicopathological  parameters were evaluated. \n<jats:italic>Results<\/jats:italic>. There were 20 patients (9 men, 11 women; mean age 58 years) identified. The primary tumor was located in the  pancreatic head (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:mrow><\/mml:math>, 45%), in pancreatic tail (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:mrow><\/mml:math>, 45%), and in the papilla Vateri (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:math>, 10%). Metastases were located in the liver (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>14<\/mml:mn><\/mml:mrow><\/mml:math>, 70%), peritoneum (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>5<\/mml:mn><\/mml:mrow><\/mml:math>, 25%), and omentum majus (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:math>, 10%). Lymphnode metastases were present in 16 patients (80%). All patients received resection of their tumors together with metastasectomy. Pylorus preserving duodenopancreatectomy was performed in 8 patients, distal pancreatectomy in 8, duodenopancreatectomy in 2, and total pancreatectomy in 2. Morbidity was 45% and there was no perioperative mortality. Median postoperative survival was 10.7 months (2.6\u201337.7\u2009months) which was not significantly different from a matched-pair group of patients who underwent pancreatic resection for UICC adenocarcinoma of the pancreas (median survival 15.6\u2009months; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.1<\/mml:mn><\/mml:mrow><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. Pancreatic resection for M1 periampullary cancer of the pancreas can be performed safely in well-selected patients. However, indication for surgery has to be made on an individual basis.<\/jats:p>","DOI":"10.1155\/2010\/579672","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T12:05:21Z","timestamp":1292328321000},"page":"1-6","source":"Crossref","is-referenced-by-count":38,"title":["Pancreatic Resections for Advanced M1-Pancreatic Carcinoma: The Value of Synchronous Metastasectomy"],"prefix":"10.1155","volume":"2010","author":[{"given":"S. K.","family":"Seelig","sequence":"first","affiliation":[{"name":"Department of Gynecology, North-West-Hospital Frankfurt, Academic Teaching Hospital, University of Frankfurt, Steinbacher Hohl 2-26, 60488 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Burkert","sequence":"additional","affiliation":[{"name":"Department of General Surgery, St. Joseph Hospital, Ruhr-University, Gudrunstra\u03b2e 56, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Chromik","sequence":"additional","affiliation":[{"name":"Department of General Surgery, St. Joseph Hospital, Ruhr-University, Gudrunstra\u03b2e 56, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tannapfel","sequence":"additional","affiliation":[{"name":"Institute for Pathology, BG Kliniken Bergmannsheil, Ruhr-University, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Uhl","sequence":"additional","affiliation":[{"name":"Department of General Surgery, St. Joseph Hospital, Ruhr-University, Gudrunstra\u03b2e 56, 44791 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Seelig","sequence":"additional","affiliation":[{"name":"Department of Surgery, Clinics of the Main Taunus County, Academic Teaching Hospital, University of Frankfurt, Kronberger Stra\u03b2e 36, 65812 Bad Soden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.06.332"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000259993.17350.3a"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23074"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9131-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0273-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5716"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00051-5"},{"issue":"6","key":"8","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1200\/JCO.1997.15.6.2403","volume":"15","year":"1997","journal-title":"Journal of Clinical Oncology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2007-0181"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-963224"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31815aab22"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000258608.52615.5a"},{"key":"13","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1200\/JCO.2006.09.0886","volume":"25","year":"2007","journal-title":"Journal of Clinical Oncology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0886"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128615"}],"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2010\/579672.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2010\/579672.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2010\/579672.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T02:20:45Z","timestamp":1607480445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/hpb\/2010\/579672\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,14]]},"references-count":15,"alternative-id":["579672","579672"],"URL":"https:\/\/doi.org\/10.1155\/2010\/579672","relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"value":"0894-8569","type":"print"},{"value":"1607-8462","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,14]]}}}