{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:34Z","timestamp":1787775694115,"version":"build-2784847793"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["IN-213108"],"award-info":[{"award-number":["IN-213108"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomedicine and Biotechnology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Taenia solium<\/jats:italic>cysticercosis is a health problem in underdeveloped and developed countries. Sex hormones are involved in cysticercosis prevalence in female and male pigs. Here, we evaluated the effects of progesterone and its antagonist RU486 on scolex evagination, which is the initial step in the development of the adult worm. Interestingly, progesterone increased<jats:italic>T. solium<\/jats:italic>scolex evagination and worm growth, in a concentration-independent pattern. Progesterone effects could be mediated by a novel<jats:italic>T. solium<\/jats:italic>progesterone receptor (TsPR), since RU486 inhibits both scolex evagination and worm development induced by progesterone. Using RT-PCR and western blot, sequences related to progesterone receptor were detected in the parasite. A phylogenetic analysis reveals that TsPR is highly related to fish and amphibian progesterone receptors, whereas it has a distant relation with birds and mammals. Conclusively, progesterone directly acts upon<jats:italic>T. solium<\/jats:italic>cysticerci, possibly through its binding to a progesterone receptor synthesized by the parasite.<\/jats:p>","DOI":"10.1155\/2010\/591079","type":"journal-article","created":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T06:47:20Z","timestamp":1260773240000},"page":"1-10","source":"Crossref","is-referenced-by-count":17,"title":["Progesterone Induces Scolex Evagination of the Human Parasite<i>Taenia solium<\/i>: Evolutionary Implications to the Host-Parasite Relationship"],"prefix":"10.1155","volume":"2010","author":[{"given":"Galileo","family":"Escobedo","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, AP 70228, 04510 M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Camacho-Arroyo","sequence":"additional","affiliation":[{"name":"Departamento 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