{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:53:14Z","timestamp":1762505594110},"reference-count":17,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Palmoplantar keratoderma is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of palms and soles. Hypothyroidism is an unusual cause of palmoplantar keratoderma, rarely reported in the literature. We report a case of a 43-year-old woman presented with a 3-month history of a diffuse palmoplantar hyperkeratosis unresponsive to topical keratolytics and corticosteroids. Her past medical and family histories were unremarkable. She complained of recent asthenia, mood changes and constipation. Laboratory evaluation revealed an autoimmune thyroiditis with hypothyroidism. Other causes of acquired palmoplantar keratoderma were excluded. After hormonal replacement therapy institution, a gradual improvement of skin condition was observed. The diagnosis of underlying causes for acquired palmoplantar keratoderma can be a difficult task; however its recognition is essential for successful treatment results. Although a very rare association, hypothyroidism must be suspected in patients with acquired palmoplantar keratoderma, particularly when it occurs in association with systemic symptoms.<\/jats:p>","DOI":"10.1155\/2010\/604890","type":"journal-article","created":{"date-parts":[[2010,3,14]],"date-time":"2010-03-14T15:30:21Z","timestamp":1268580621000},"page":"1-3","source":"Crossref","is-referenced-by-count":7,"title":["Autoimmune Thyroiditis Presenting as Palmoplantar Keratoderma"],"prefix":"10.1155","volume":"2010","author":[{"given":"Sara","family":"Lestre","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital de Santo Ant\u00f3nio dos Capuchos, 1150-314 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Lozano","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital de Santo Ant\u00f3nio dos Capuchos, 1150-314 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Meireles","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital de Santo Ant\u00f3nio dos Capuchos, 1150-314 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Barata Feio","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital de Santo Ant\u00f3nio dos Capuchos, 1150-314 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708010-00001"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000249351","volume":"172","year":"1986","journal-title":"Dermatologica"},{"issue":"1","key":"3","first-page":"45","volume":"21","year":"2001","journal-title":"Journal of Experimental and Clinical Cancer Research"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07197.x"},{"issue":"8","key":"5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1001\/archfami.9.8.743","volume":"9","year":"2000","journal-title":"Archives of Family Medicine"},{"issue":"8","key":"6","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/BF03343905","volume":"24","year":"2001","journal-title":"Journal of Endocrinological Investigation"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-4310(98)01428-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.09.005"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2007.09.021"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.257"},{"issue":"2","key":"11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/archderm.1952.01530270055007","volume":"66","year":"1952","journal-title":"Archives of Dermatology and Syphilology"},{"issue":"3","key":"12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2230.1977.tb02572.x","volume":"2","year":"1977","journal-title":"Clinical and Experimental Dermatology"},{"issue":"4","key":"13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2340\/0001555566354357","volume":"66","year":"1986","journal-title":"Acta Dermato-Venereologica"},{"issue":"5","key":"14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2230.1988.tb00718.x","volume":"13","year":"1988","journal-title":"Clinical and Experimental Dermatology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02480.x"},{"issue":"4","key":"16","first-page":"242","volume":"68","year":"2002","journal-title":"Indian Journal of Dermatology, Venereology and Leprology"},{"issue":"1","key":"17","first-page":"47","volume":"65","year":"2005","journal-title":"Medicina"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2010\/604890.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2010\/604890.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2010\/604890.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T02:58:55Z","timestamp":1711335535000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crim\/2010\/604890\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":17,"alternative-id":["604890","604890"],"URL":"https:\/\/doi.org\/10.1155\/2010\/604890","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}