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Although existing diabetes animal models also develop ocular complications, severe retinal lesions frequently observed in human diabetes patients such as preretinal neovascularization or retinal detachment are not found. Distinctive features in SDT rat are hypermature cataract, tractional retinal detachment with fibrous proliferation, and massive hemorrhaging in the anterior chamber. These pathophysiological changes are caused by sustained hyperglycemic condition and subsequent increased expression of vascular endothelial growth factor (VEGF) in retina, iris, and ciliary body. Although some differences in diabetic retinopathy exist between SDT rats and humans (e.g., a low incidence of neovascular formation and poor development of nonperfused area are found in this animal), SDT rat will be a useful model in studies of the pathogenesis and treatment of diabetic retinopathy.<\/jats:p>","DOI":"10.1155\/2010\/615641","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T14:34:08Z","timestamp":1274798048000},"page":"1-7","source":"Crossref","is-referenced-by-count":13,"title":["Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat"],"prefix":"10.1155","volume":"2010","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-6052","authenticated-orcid":true,"given":"Tomohiko","family":"Sasase","sequence":"first","affiliation":[{"name":"Biological\/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 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