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At 3 Tesla (T), MT affords higher resolution and increased tissue contrast associated with macromolecules. The reliability and reproducibility of a new high\u2010resolution MT strategy were assessed in brain images acquired from 9 healthy subjects. Repeated measures were taken for 12 brain regions of interest (ROIs): genu, splenium, and the left and right hemispheres of the hippocampus, caudate, putamen, thalamus, and cerebral white matter. Spearman\u2032s correlation coefficient, coefficient of variation, and intraclass correlation coefficient (ICC) were computed. Multivariate mixed\u2010effects regression models were used to fit the mean ROI values and to test the significance of the effects due to region, subject, observer, time, and manual repetition. A sensitivity analysis of various model specifications and the corresponding ICCs was conducted. Our statistical methods may be generalized to many similar evaluative studies of the reliability and reproducibility of various imaging modalities.<\/jats:p>","DOI":"10.1155\/2010\/618747","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T15:30:52Z","timestamp":1265729452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Statistical Evaluations of the Reproducibility and Reliability of 3\u2010Tesla High Resolution Magnetization Transfer Brain Images: A Pilot Study on Healthy Subjects"],"prefix":"10.1155","volume":"2010","author":[{"given":"Kelly H.","family":"Zou","sequence":"first","affiliation":[]},{"given":"Hongyan","family":"Du","sequence":"additional","affiliation":[]},{"given":"Shawn","family":"Sidharthan","sequence":"additional","affiliation":[]},{"given":"Lisa M.","family":"DeTora","sequence":"additional","affiliation":[]},{"given":"Yunmei","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Ann B.","family":"Ragin","sequence":"additional","affiliation":[]},{"given":"Robert R.","family":"Edelman","sequence":"additional","affiliation":[]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,2,9]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10028"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10244"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl208"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21302"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.11.028"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.053"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0740"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2007.06.005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10334\u2010006\u20100049\u20108"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780140308"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u2010510X(95)00093\u2010H"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"volume-title":"Statistical Inference Based on Ranks","year":"1991","author":"Hettmansperger T. 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