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The structure of [Ph<jats:sub>2<\/jats:sub>(HyFoSc)Sn] was confirmed by single\u2010crystal X\u2010ray crystallography. The doubly deprotonated ligand is coordinated to the tin atom through the enolic\u2010oxygen, the azomethine\u2010nitrogen, and phenolic\u2010oxygen, and so acts as an anionic tridentate ligand with the ONO donors.  Two carbon atoms complete the fivefold coordination at the tin(IV) center. Intermolecular hydrogen bonding, C\u2013H \u2192 <jats:italic>\u03c0<\/jats:italic>, and <jats:italic>\u03c0<\/jats:italic> \u2192 <jats:italic>\u03c0<\/jats:italic> interactions combine to stabilize the crystal structure. Compounds <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> have been evaluated for antiproliferative activity in vitro against the cells of three human tumor cell lines: MCF\u20107 (human breast cancer cell line), T24 (bladder cancer cell line), A549 (nonsmall cell lung carcinoma), and a mouse fibroblast L\u2010929 cancer cell line.<\/jats:p>","DOI":"10.1155\/2010\/718606","type":"journal-article","created":{"date-parts":[[2010,5,12]],"date-time":"2010-05-12T14:32:47Z","timestamp":1273674767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Organotin Compound Derived from 3\u2010Hydroxy\u20102\u2010formylpyridine  Semicarbazone: Synthesis, Crystal Structure, and  Antiproliferative Activity"],"prefix":"10.1155","volume":"2010","author":[{"given":"Joanna","family":"Wiecek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Kovala-Demertzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Ciunik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Wietrzyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Zervou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mavroudis A.","family":"Demertzis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,12]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010\u20108545(02)00178\u20109"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.331"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2005.11.058"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200490175"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2005.02.004"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2005.12.033"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557043487484"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2003.11.004"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010\u20108545(00)00363\u20105"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162\u20100134(97)00087\u20101"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162\u20100134(00)00063\u20105"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001813\u2010200101000\u201000009"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162\u20100134(01)00224\u20100"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007154"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0162\u20100134(02)00493\u20102"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022543718598"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/56165"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522\u20102675(20001004)83:10<2787::AID\u2010HLCA2787>3.0.CO;2\u20106"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/ejic.200200514","article-title":"Organotin-drug interactions. 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