{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:52:27Z","timestamp":1770965547548,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["2002.B033"],"award-info":[{"award-number":["2002.B033"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["LSHM-CT-2003-503254"],"award-info":[{"award-number":["LSHM-CT-2003-503254"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"crossref","award":["BSIK 03033"],"award-info":[{"award-number":["BSIK 03033"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Community\u2019s Sixth Framework Program for Research","award":["2002.B033"],"award-info":[{"award-number":["2002.B033"]}]},{"name":"European Community\u2019s Sixth Framework Program for Research","award":["LSHM-CT-2003-503254"],"award-info":[{"award-number":["LSHM-CT-2003-503254"]}]},{"name":"European Community\u2019s Sixth Framework Program for Research","award":["BSIK 03033"],"award-info":[{"award-number":["BSIK 03033"]}]},{"name":"Besluit Subsidies Investeringen Kennisinfrastructuur","award":["2002.B033"],"award-info":[{"award-number":["2002.B033"]}]},{"name":"Besluit Subsidies Investeringen Kennisinfrastructuur","award":["LSHM-CT-2003-503254"],"award-info":[{"award-number":["LSHM-CT-2003-503254"]}]},{"name":"Besluit Subsidies Investeringen Kennisinfrastructuur","award":["BSIK 03033"],"award-info":[{"award-number":["BSIK 03033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Vascular Medicine"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.<\/jats:p>","DOI":"10.1155\/2010\/726207","type":"journal-article","created":{"date-parts":[[2010,5,30]],"date-time":"2010-05-30T15:31:38Z","timestamp":1275233498000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Leukocyte Counts, Myeloperoxidase, and Pregnancy-Associated Plasma Protein A as Biomarkers for Cardiovascular Disease: Towards a Multi-Biomarker Approach"],"prefix":"10.1155","volume":"2010","author":[{"given":"M. B. I.","family":"Lobbes","sequence":"first","affiliation":[{"name":"Department of Pathology, Cardiovascular Research Institute Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands"},{"name":"Department of Radiology, Maastricht University Medical Center, P.O. 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