{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:00:01Z","timestamp":1772784001249,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30872361"],"award-info":[{"award-number":["30872361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2007BAI18B10"],"award-info":[{"award-number":["2007BAI18B10"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Technology R&D Program in the 11th Five Year Plan of China","award":["30872361"],"award-info":[{"award-number":["30872361"]}]},{"name":"National Key Technology R&D Program in the 11th Five Year Plan of China","award":["2007BAI18B10"],"award-info":[{"award-number":["2007BAI18B10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To observe the expression of Toll-like receptor-4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear factor kappa B p65 (NF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B p65) in iris tissue during endotoxin-induced uveitis (EIU) and evaluate the significance of these factors in uveitis.<jats:italic>Methods<\/jats:italic>. Wistar rats were randomly divided into 5 groups (0\u2009h, 12\u2009h, 24\u2009h, 48\u2009h, and 72\u2009h, n = 10\/group). Animal model of acute anterior uveitis was established by a hind footpad injection of 200\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03bc<\/mml:mi><mml:mtext>g<\/mml:mtext><\/mml:math>Cholera vibrio LPS. Expression of TLR4, MyD88, and NF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B p65 in iris ciliary body tissue was detected through immunohistochemical staining.<jats:italic>Results<\/jats:italic>. Expression of TLR4 was not detected in normal iris-ciliary body complex, TLR4 positive cells with round morphology appeared in the iris stroma 12 hours after injection, significantly increased<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.001<\/mml:mn><\/mml:mrow><mml:mo>)<\/mml:mo><\/mml:mrow><\/mml:math>48 hours after injection, and decreased gradually 72 hours after injection. Expression of MyD88 and NF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B p65 is consistent with the change of the TLR4.<jats:italic>Conclusions<\/jats:italic>. The increased expression of TLR4 and its downstream signal transduction moleculesMyD88, NF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B p65 indicate the potential role of pathway in the pathogenesis of acute anterior uveitis (AAU).<\/jats:p>","DOI":"10.1155\/2010\/748218","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T14:40:21Z","timestamp":1280846421000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Expression of TLR4-MyD88 and NF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03ba<\/mml:mi><\/mml:math>B in the Iris during Endotoxin-Induced Uveitis"],"prefix":"10.1155","volume":"2010","author":[{"given":"Shang","family":"Li","sequence":"first","affiliation":[{"name":"Departmnet of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Departmnet of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Departmnet of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Haidian Maternal and Child Health Hospital, Tonji Medical University, Beijing 100080, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhi","family":"Xu","sequence":"additional","affiliation":[{"name":"Departmnet of Ophthalmology, 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