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Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA.<\/jats:p>","DOI":"10.1155\/2010\/759868","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T19:35:32Z","timestamp":1291318532000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["B-Cell Pathology in Juvenile Idiopathic Arthritis"],"prefix":"10.1155","volume":"2010","author":[{"given":"V.","family":"Wiegering","sequence":"first","affiliation":[{"name":"Pediatric Hematology, Oncology and Neurooncology, Pediatric Stem Cell Transplantation Program, Children's Hospital, University of W\u00fcrzburg, Josef-Schneider-Str. 2, 97080 W\u00fcrzburg, Germany"},{"name":"Pediatric Rheumatology, Immunology and Infectious Diseases, Children's Hospital, University of W\u00fcrzburg, Josef-Schneider-Str. 2, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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