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A Th2 response to<jats:italic>S. mansoni<\/jats:italic>infection or its antigens is key to both the establishment of tolerance and successfully reproduction in the host. More recently we demonstrated that SEA treatment upregulates bioactive TGF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>on T cells with consequent expansion of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mtext>Foxp<\/mml:mtext><mml:msup><mml:mn>3<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:mrow><\/mml:math>Tregs, and these cells might be important in SEA-mediated diabetes prevention together with Th2 cells. In this study we profile further the phenotypic changes that SEA induces on APCs, with particular attention to cytokine expression and markers of macrophage alternative activation. Our studies suggest that TGF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b2<\/mml:mi><\/mml:math>from T cells is important not just for Treg expansion but also for the successful Th2 response to SEA, and therefore, for diabetes prevention in the NOD mouse.<\/jats:p>","DOI":"10.1155\/2010\/795210","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T10:29:12Z","timestamp":1267439352000},"page":"1-11","source":"Crossref","is-referenced-by-count":80,"title":["Immune Modulation by<i>Schistosoma mansoni<\/i>Antigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems"],"prefix":"10.1155","volume":"2010","author":[{"given":"Paola","family":"Zaccone","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QP Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver 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