{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:27:08Z","timestamp":1787156828323,"version":"build-2736575974"},"reference-count":43,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Higher Education, Cairo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>To explore the feasibility of detecting salivary levels of IFN-\u03b3, TNF-\u03b1, and sTNFR-2 from erosive oral lichen planus (ELP) patients for clinical application, 20 ELP patients were enrolled in the study as were 20 age-sex-matched controls. From all subjects, saliva level of the tested biomarkers was determined by ELISA. Salivary profiles were assessed in ELP patients by ELISA after being treated with prednisone. A significantly higher level of IFN-\u03b3 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>.01<\/mml:mn><\/mml:math>), TNF-\u03b1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>.0001<\/mml:mn><\/mml:math>), and sTNFR-2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>.01<\/mml:mn><\/mml:math>) was detected in ELP patients before treatment than in controls. Following treatment, the salivary levels of IFN-\u03b3 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>.01<\/mml:mn><\/mml:math>), TNF-\u03b1 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>.05<\/mml:mn><\/mml:math>), and sTNFR-2 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>.01<\/mml:mn><\/mml:math>) decreased significantly when compared to their pretreatment levels. This study demonstrated that salivary IFN-\u03b3, TNF-\u03b1, and sTNFR-2 can be detectable in ELP patients and decreased significantly after treatment with prednisone, which may reveal the possibility of using these disease-related biomarkers in diagnosis and monitoring.<\/jats:p>","DOI":"10.1155\/2010\/847632","type":"journal-article","created":{"date-parts":[[2011,2,13]],"date-time":"2011-02-13T19:35:34Z","timestamp":1297625734000},"page":"1-7","source":"Crossref","is-referenced-by-count":42,"title":["Levels of Salivary IFN-gamma, TNF-Alfa, and TNF Receptor-2 As Prognostic Markers in (Erosive) Oral Lichen Planus"],"prefix":"10.1155","volume":"2010","author":[{"given":"Noha A.","family":"Ghallab","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Cairo University, 43 Zahraa Street, Dokki, Giza 12311, 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