{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:32Z","timestamp":1791174692706,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["60956-M"],"award-info":[{"award-number":["60956-M"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomedicine and Biotechnology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p><jats:italic>Taenia crassiceps<\/jats:italic>, like other helminths, can exert regulatory effects on the immune system of its host. This study investigates the effect of chronic<jats:italic>T. crassiceps<\/jats:italic>infection on the outcome of Multiple Low Dose Streptozotocin-Induced Diabetes (MLDS). Healthy or previously<jats:italic>T. crassiceps<\/jats:italic>-infected mice received MLDS and type 1 diabetes (T1D) symptoms were evaluated for 6 weeks following the induction of MLDS.<jats:italic>T. crassiceps<\/jats:italic>-infected mice displayed lower blood glucose levels throughout the study. A significantly lower percentage of<jats:italic>T. crassiceps<\/jats:italic>-infected mice (40%) developed T1D compared to the uninfected group (100%). Insulitis was remarkably absent in<jats:italic>T. crassiceps<\/jats:italic>-infected mice, which had normal pancreatic insulin content, whereas uninfected mice showed a dramatic reduction in pancreatic insulin. Infected mice that received MLDS did not show an increase in their regulatory T cell population, however, they had a greater number of alternatively activated macrophages, higher levels of the cytokine IL-4, and lower levels of TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>\u03b1<\/mml:mi><\/mml:math>. Therefore, infection with<jats:italic>T. crassiceps<\/jats:italic>causes an immunomodulation that modifies the incidence and development of MLDS-induced autoimmune diabetes.<\/jats:p>","DOI":"10.1155\/2010\/850541","type":"journal-article","created":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T15:30:44Z","timestamp":1262619044000},"page":"1-11","source":"Crossref","is-referenced-by-count":44,"title":["<i>Taenia crassiceps<\/i>Infection Attenuates Multiple Low-Dose Streptozotocin-Induced Diabetes"],"prefix":"10.1155","volume":"2010","author":[{"given":"Arlett","family":"Espinoza-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla, M\u00e9xico 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Rivera-Montoya","sequence":"additional","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios 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