{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:07:53Z","timestamp":1782439673411,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T00:00:00Z","timestamp":1265241600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obstetrics and Gynecology International"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Postmenopausal bleeding (PMB) is a common clinical problem. Patients with PMB have 10%\u201315% chance of having endometrial carcinoma and therefore the diagnostic workup is aimed at excluding malignancy. Patient characteristics can alter the probability of having endometrial carcinoma in patients with PMB; in certain groups of patients the incidence has been reported to be as high as 29%. Transvaginal sonography (TVS) is used as a first step in the diagnostic workup, but different authors have come to different conclusions assessing the accuracy of TVS for excluding endometrial carcinoma. Diagnostic procedures obtaining material for histological assessment (e.g., dilatation and curettage, hysteroscopy, and endometrial biopsy) can be more accurate but are also more invasive. The best diagnostic strategy for diagnosing endometrial carcinoma in patients with PMB still remains controversial. Future research should be focussed on achieving a higher accuracy of different diagnostic strategies.<\/jats:p>","DOI":"10.1155\/2010\/850812","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T15:30:27Z","timestamp":1265297427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Diagnostic Strategies for Postmenopausal Bleeding"],"prefix":"10.1155","volume":"2010","author":[{"given":"M. C.","family":"Breijer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Timmermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W. J.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. C.","family":"Opmeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,4]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00914.x"},{"key":"e_1_2_5_2_2","volume-title":"Diagnosis of Uterine Cavity Abnormalities. Studies on Test Performace and Clinical Value","author":"Dijkhuizen F. P.","year":"2000"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.00400.x"},{"key":"e_1_2_5_4_2","first-page":"232","article-title":"Histopathological findings in women with postmenopausal bleeding in Jamaica","volume":"51","author":"Escoffery C. T.","year":"2002","journal-title":"West Indian Medical Journal"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb09066.x"},{"key":"e_1_2_5_6_2","first-page":"164","article-title":"The aetiology of postmenopausal bleeding\u2013a study of 163 consecutive cases in Singapore","volume":"36","author":"Lee W. H.","year":"1995","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348609158227"},{"key":"e_1_2_5_8_2","first-page":"241","article-title":"Clinical study of 381 postmenopausal bleeding patients","volume":"92","author":"Lin H. H.","year":"1993","journal-title":"Journal of the Formosan Medical Association"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.801210.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20415"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1440"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2004.00357.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2001.20.10.1025"},{"key":"e_1_2_5_14_2","unstructured":"NVOG (Dutch Society of Obstetrics and Gynaecology) NVOG-richtlijn Abnormaal Vaginaal Bloedverlies in de Menopauze [in Dutch]. 2003."},{"key":"e_1_2_5_15_2","volume-title":"Investigation of Postmenopausal Bleeding","author":"Scottish Intercollegiate Guidelines Network","year":"2002"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.810902.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.17.1510"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01771-9"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443619750112989"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(95)00945-0"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349609033357"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03233.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000136080.55874.7f"},{"key":"e_1_2_5_24_2","first-page":"537","article-title":"Prehysterectomy curettage","volume":"45","author":"Stock R. J.","year":"1975","journal-title":"Obstetrics & Gynecology"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08358.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001015)89:8<1765::AID-CNCR17>3.0.CO;2-F"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.05.040"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90011-7"},{"key":"e_1_2_5_29_2","first-page":"16","article-title":"Hysteroscopy with selective endometrial sampling compared with D&C for abnormal uterine bleeding: the value of a negative hysteroscopic view","volume":"73","author":"Loffer F. D.","year":"1989","journal-title":"Obstetrics & Gynecology"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(97)80019-9"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000084241.09900.c8"},{"key":"e_1_2_5_32_2","first-page":"611","article-title":"Diabetes and endometrial cancer in the Iowa Women\u2032s Health Study","volume":"10","author":"Anderson K. E.","year":"2001","journal-title":"Cancer Epidemiology Biomarkers and Prevention"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.115869"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008707"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008946825313"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11598"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01168.x"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00098-8"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20020"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2003.00176.x"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02234.x"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-9-22"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp013"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15109.x"}],"container-title":["Obstetrics and Gynecology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ogi\/2010\/850812.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ogi\/2010\/850812.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2010\/850812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T16:30:47Z","timestamp":1722875447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2010\/850812"}},"subtitle":[],"editor":[{"given":"Robert","family":"Mclellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1155\/2010\/850812"],"URL":"https:\/\/doi.org\/10.1155\/2010\/850812","archive":["Portico"],"relation":{},"ISSN":["1687-9589","1687-9597"],"issn-type":[{"value":"1687-9589","type":"print"},{"value":"1687-9597","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"2009-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"850812"}}