{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:35:59Z","timestamp":1775511359198,"version":"3.50.1"},"reference-count":0,"publisher":"Hindawi Limited","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>BACKGROUND: The interpretation of methacholine test results do not usually consider the symptoms for which the subject was referred and those that occur during the test.<\/jats:p><jats:p>OBJECTIVE: To assess the association between methacholine test results and symptoms, and to examine variables that may affect this association.<\/jats:p><jats:p>METHODS: A total of 400 prospectively chosen subjects who underwent methacholine testing for possible asthma were investigated. The subjects answered a short questionnaire regarding the symptoms for which they had been referred and those that were encountered during the methacholine test.<\/jats:p><jats:p>RESULTS: The positive predictive value for the reproduction of symptoms during the test compared with symptoms for which subjects had been referred were 84% for dyspnea, 87% for cough, 81% for wheezing and 72% for chest tightness. The positive predictive value among the values obtained by measuring the provocative concentration of methacholine causing a 20% fall (PC<jats:sub>20<\/jats:sub>) in forced expiratory volume in 1 s on the one hand, and specific symptoms on the other, varied by up to approximately 50%; negative predictive values were higher. Forty-eight per cent of subjects with a PC<jats:sub>20<\/jats:sub>of 16 mg\/mL or lower reported that the test had globally reproduced their symptoms. This association was significantly stronger in women, young subjects and those taking inhaled steroids.<\/jats:p><jats:p>CONCLUSIONS: The methacholine test generally reproduced the symptoms for which the subjects were referred. The absence of a specific symptom (eg, dyspnea, cough, wheezing or chest tightness), either in daily life or at the time of methacholine testing, was more generally associated with a negative test than the reverse. The global impression that the test had reproduced what the patient had experienced in daily life was significantly associated with a positive test (ie, a PC<jats:sub>20<\/jats:sub>of 16 mg\/mL or lower), with the association being stronger in young subjects and women.<\/jats:p>","DOI":"10.1155\/2010\/908147","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T04:07:17Z","timestamp":1458014837000},"page":"224-228","source":"Crossref","is-referenced-by-count":4,"title":["Does the Methacholine Test Reproduce Symptoms?"],"prefix":"10.1155","volume":"17","author":[{"given":"Marianne","family":"L\u00e9vesque","sequence":"first","affiliation":[{"name":"Department of Chest Medicine, Sacr\u00e9-Coeur Hospital, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heberto","family":"Ghezzo","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Sacr\u00e9-Coeur Hospital, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"L\u2019Archev\u00eaque","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Sacr\u00e9-Coeur Hospital, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Malo","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine, Sacr\u00e9-Coeur Hospital, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2010\/908147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2010\/908147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T12:07:10Z","timestamp":1471954030000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crj\/2010\/908147\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010]]}},"alternative-id":["908147"],"URL":"https:\/\/doi.org\/10.1155\/2010\/908147","relation":{},"ISSN":["1198-2241"],"issn-type":[{"value":"1198-2241","type":"print"}],"subject":[],"published":{"date-parts":[[2010]]}}}