{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:49:56Z","timestamp":1778809796565,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary Sj\u00f6gren's syndrome, sarcoidosis, mixed connective tissue disease, vasculitis, CREST syndrome, and polymyositis) and in 15 healthy female controls. There were no statistically significant differences between the patients and controls with regard to serum leptin, serum ghrelin, global fat mass, adiposity, and fat mass in the android or gynoid regions, whereas serum adiponectin levels were higher in patients than controls (\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL versus \u2009<jats:italic>\u03bc<\/jats:italic>g\/mL; ). As adiponectin is known to exhibit potent anti-inflammatory properties, a high adiponectinemia in patients with systemic autoimmune disease may mitigate the inflammatory response. However, the precise consequences of these elevated serum adiponectin levels on the metabolic syndrome development and atherosclerotic cardiovascular risk in this patient population still needs to be determined.<\/jats:p>","DOI":"10.1155\/2010\/938408","type":"journal-article","created":{"date-parts":[[2010,12,26]],"date-time":"2010-12-26T14:37:31Z","timestamp":1293374251000},"page":"1-6","source":"Crossref","is-referenced-by-count":34,"title":["Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases"],"prefix":"10.1155","volume":"2010","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6228-1464","authenticated-orcid":true,"given":"\u00c9ric","family":"Toussirot","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besan\u00e7on Cedex, France"},{"name":"University Hospital St Jacques, CIC Biotherapy-CBT 506, 25030 Besan\u00e7on Cedex, France"},{"name":"University of Franche Comt\u00e9, \u00c9quipe d'Accueil 4266 \u201cAgents Pathog\u00e8nes et Inflammation\u201d, IFR133, 25000 Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Gaugler","sequence":"additional","affiliation":[{"name":"University Hospital St Jacques, CIC Biotherapy-CBT 506, 25030 Besan\u00e7on Cedex, France"},{"name":"INSERM UMR645, 1 Bd A Fleming, 25020 Besan\u00e7on Cedex, France"},{"name":"University of Franche-Comt\u00e9, UMR645, IFR133, 25020 Besan\u00e7on Cedex, France"},{"name":"EFS Bourgogne Franche-Comt\u00e9, Plateforme de Biomonitoring, 25020 Besan\u00e7on Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Bouhaddi","sequence":"additional","affiliation":[{"name":"Department of Physiology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besan\u00e7on Cedex, France"},{"name":"University of Franche Comt\u00e9, \u00c9quipe d'Accueil EA 3920 \u201cPhysiopathologie Cardiovasculaire et 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