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To investigate the influences of IVM on epigenetic reprogramming and to search for the possible reasons for the lower rates of fertilization and cleavage in IVM oocytes, we examined the expression of two enzymes controlling histone acetylation, histone acetyltransferase GCN5 (GCN5) and histone deacetylase 1 (HDAC1), as well as their common target, acetyl\u2010histone H3 (Ac\u2010H3), in mouse metaphase II (MII) oocytes and preimplantation embryos. Results showed that IVM downregulated the protein expression of GCN5 in MII oocytes and two\u2010cell embryos and changed the distribution of GCN5 in two\u2010cell embryos. Expression of HDAC1 mRNA in MII oocytes and two\u2010cell embryos decreased in the IVM group. However, none of these changes persisted after two\u2010cell embryos. Levels of Ac\u2010H3 in both oocytes and embryos remained unchanged after IVM. Our studies indicated that IVM could affect the protein and gene expression related to histone acetylation in oocytes and early cleavage embryos. By function of selection, parts of the changes could be recovered in late embryo development.<\/jats:p>","DOI":"10.1155\/2010\/989278","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T05:40:56Z","timestamp":1277098856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of In Vitro Maturation on Histone Acetylation in Metaphase II Oocytes and Early Cleavage 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