{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:29:16Z","timestamp":1787678956518,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,11,7]],"date-time":"2010-11-07T00:00:00Z","timestamp":1289088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>\n                    Amla (\n                    <jats:italic>Phyllanthus emblica<\/jats:italic>\n                    L.), apart from its food value, can be used as a gastroprotective agent in non steroidal anti\u2010inflammatory drug (NSAID)\u2010induced gastropathy. It has been suggested that the antioxidative property of amla is the key to its therapeutic effect. Hence, on the basis of\n                    <jats:italic>in vitro<\/jats:italic>\n                    antioxidative potential, the ethanolic extract of amla (eAE) was selected for\n                    <jats:italic>in vivo<\/jats:italic>\n                    study in NSAID\u2010induced ulcer. Intriguingly, eAE showed biphasic activity in ulcerated mice, with healing effect observed at 60\u2009mg\/kg and an adverse effect at 120\u2009mg\/kg.The dose\u2010dependent study revealed that switching from anti\u2010oxidant to pro\u2010oxidant shift and immunomodulatory property could be the major cause for its biphasic effect, as evident from the total antioxidant status, thiol concentration, lipid peroxidation, protein carbonyl content followed by mucin content, PGE\n                    <jats:sub>2<\/jats:sub>\n                    synthesis and cytokine status. Further, Buthionine sulfoxamine (BSO) pretreatment established the potential impact of antioxidative property in the healing action of eAE. However, eAE efficiently reduced pro\u2010inflammatory cytokine (TNF\u2010\u03b1 and IL\u20101\u03b2) levels and appreciably upregulate anti\u2010inflammatory cytokine (IL\u201010) concentration. In conclusion, gastric ulcer healing induced by eAE was driven in a dose\u2010specific manner through the harmonization of the antioxidative property and modulation of anti\u2010inflammatory cytokine level.\n                  <\/jats:p>","DOI":"10.1155\/2011\/146808","type":"journal-article","created":{"date-parts":[[2010,11,7]],"date-time":"2010-11-07T14:33:31Z","timestamp":1289140411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Biphasic Effect of\n                    <i>Phyllanthus emblica<\/i>\n                    L. Extract on NSAID\u2010InducedUlcer: An Antioxidative Trail Weaved with Immunomodulatory Effect"],"prefix":"10.1155","volume":"2011","author":[{"given":"Ananya","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandip K.","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,7]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"3","article-title":"Antimicrobial activity of certain Sudanese plants used in folkloric medicine. Screening for antibacterial activity (I)","volume":"54","author":"Farouk A.","year":"1983","journal-title":"Fitoterapia"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(98)00055\u20105"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010957754"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1367"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nem030"},{"key":"e_1_2_7_6_2","first-page":"187","article-title":"Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: effects on in vitro cell growth of human tumor cell lines","volume":"21","author":"Khan M. T.","year":"2002","journal-title":"International Journal of Oncology"},{"key":"e_1_2_7_7_2","first-page":"419","article-title":"Effects of extracts from Bangladeshi medicinal plants on in vitro proliferation of human breast cancer cell lines and expression of estrogen receptor alpha gene","volume":"24","author":"Lambertini E.","year":"2004","journal-title":"International Journal of Oncology"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(99)00146\u20104"},{"key":"e_1_2_7_9_2","article-title":"Acid balancing effect on digestive system:clinical studies were conducted to investigate the effect of amalaki in amlapitta (Gastritis syndrome)","author":"Singh","year":"1971","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_7_10_2","first-page":"315","article-title":"Non-steroidal drug-induced gastrointestinal toxicity: mechanisms and management","volume":"4","author":"Dhikav V.","year":"2003","journal-title":"Indian Journal of Clinical Medicine"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.59.11.0014"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.5.2434"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20108741(94)90099\u2010X"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99728-0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.09.041"},{"key":"e_1_2_7_17_2","first-page":"481","article-title":"L-carnitine inhibits ethanol-induced gastric mucosal injury in rats","volume":"57","author":"Dokmeci D.","year":"2005","journal-title":"Pharmacological Reports"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(83)90019-2"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.3.618.618"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/546560"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076\u20106879(72)25041\u20108"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197\u20100186(00)00117\u20100"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413398200"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2004.12.003"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i27.3705"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01538126"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.145334"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210328200"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.6.732"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02265120"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026668816189"},{"key":"e_1_2_7_35_2","first-page":"126","article-title":"Improved method of total antioxidant assay","volume":"46","author":"Gupta R.","year":"2009","journal-title":"Indian Journal of Biochemistry and Biophysics"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1102"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199509000-00002"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2011\/146808.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2011\/146808.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2011\/146808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T15:18:05Z","timestamp":1718119085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2011\/146808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,7]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1155\/2011\/146808"],"URL":"https:\/\/doi.org\/10.1155\/2011\/146808","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,7]]},"assertion":[{"value":"2010-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"146808"}}