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The RNFL represents the most proximal region of the afferent visual pathway; and, as such, is a unique region of the central nervous system (CNS) because it lacks myelin. Changes in retinal integrity can be correlated with reliable and quantifiable visual outcomes to provide a structural-functional paradigm of CNS injury. Because the eye provides a unique \u201cview\u201d into the effects of CNS inflammation, the ON \u201csystem model\u201d may provide greater understanding about disease mechanisms, which underpin disability in MS. This review addresses the applications of OCT in study of ON patients, with specific reference to the published reports to date. The future role of OCT is discussed, both in terms of the potential gains and certain challenges associated with this evolving technology.<\/jats:p>","DOI":"10.1155\/2011\/148394","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T19:31:35Z","timestamp":1300822295000},"page":"1-9","source":"Crossref","is-referenced-by-count":10,"title":["Evaluating the Use of Optical Coherence Tomography in Optic Neuritis"],"prefix":"10.1155","volume":"2011","author":[{"given":"Fiona","family":"Costello","sequence":"first","affiliation":[{"name":"Departments of Clinical Neurosciences and Surgery, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 2T9"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"9","key":"1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM199202273260901","volume":"326","year":"1992","journal-title":"The New England Journal of 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