{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:38:39Z","timestamp":1772825919447,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T00:00:00Z","timestamp":1293494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30811120440"],"award-info":[{"award-number":["30811120440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30911120261"],"award-info":[{"award-number":["30911120261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["S2011GR0323"],"award-info":[{"award-number":["S2011GR0323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["08410701800"],"award-info":[{"award-number":["08410701800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CCI-92212"],"award-info":[{"award-number":["CCI-92212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CCL-99636"],"award-info":[{"award-number":["CCL-99636"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CCM 104888"],"award-info":[{"award-number":["CCM 104888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30811120440"],"award-info":[{"award-number":["30811120440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30911120261"],"award-info":[{"award-number":["30911120261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["S2011GR0323"],"award-info":[{"award-number":["S2011GR0323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["08410701800"],"award-info":[{"award-number":["08410701800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CCI-92212"],"award-info":[{"award-number":["CCI-92212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CCL-99636"],"award-info":[{"award-number":["CCL-99636"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CCM 104888"],"award-info":[{"award-number":["CCM 104888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology of China","award":["30811120440"],"award-info":[{"award-number":["30811120440"]}]},{"name":"Ministry of Science and Technology of China","award":["30911120261"],"award-info":[{"award-number":["30911120261"]}]},{"name":"Ministry of Science and Technology of China","award":["S2011GR0323"],"award-info":[{"award-number":["S2011GR0323"]}]},{"name":"Ministry of Science and Technology of China","award":["08410701800"],"award-info":[{"award-number":["08410701800"]}]},{"name":"Ministry of Science and Technology of China","award":["CCI-92212"],"award-info":[{"award-number":["CCI-92212"]}]},{"name":"Ministry of Science and Technology of China","award":["CCL-99636"],"award-info":[{"award-number":["CCL-99636"]}]},{"name":"Ministry of Science and Technology of China","award":["CCM 104888"],"award-info":[{"award-number":["CCM 104888"]}]},{"name":"Shanghai International Collaboration Foundation","award":["30811120440"],"award-info":[{"award-number":["30811120440"]}]},{"name":"Shanghai International Collaboration Foundation","award":["30911120261"],"award-info":[{"award-number":["30911120261"]}]},{"name":"Shanghai International Collaboration Foundation","award":["S2011GR0323"],"award-info":[{"award-number":["S2011GR0323"]}]},{"name":"Shanghai International Collaboration Foundation","award":["08410701800"],"award-info":[{"award-number":["08410701800"]}]},{"name":"Shanghai International Collaboration Foundation","award":["CCI-92212"],"award-info":[{"award-number":["CCI-92212"]}]},{"name":"Shanghai International Collaboration Foundation","award":["CCL-99636"],"award-info":[{"award-number":["CCL-99636"]}]},{"name":"Shanghai International Collaboration Foundation","award":["CCM 104888"],"award-info":[{"award-number":["CCM 104888"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["30811120440"],"award-info":[{"award-number":["30811120440"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["30911120261"],"award-info":[{"award-number":["30911120261"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["S2011GR0323"],"award-info":[{"award-number":["S2011GR0323"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["08410701800"],"award-info":[{"award-number":["08410701800"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCI-92212"],"award-info":[{"award-number":["CCI-92212"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCL-99636"],"award-info":[{"award-number":["CCL-99636"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCM 104888"],"award-info":[{"award-number":["CCM 104888"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["30811120440"],"award-info":[{"award-number":["30811120440"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["30911120261"],"award-info":[{"award-number":["30911120261"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["S2011GR0323"],"award-info":[{"award-number":["S2011GR0323"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["08410701800"],"award-info":[{"award-number":["08410701800"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCI-92212"],"award-info":[{"award-number":["CCI-92212"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCL-99636"],"award-info":[{"award-number":["CCL-99636"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCM 104888"],"award-info":[{"award-number":["CCM 104888"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["30811120440"],"award-info":[{"award-number":["30811120440"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["30911120261"],"award-info":[{"award-number":["30911120261"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["S2011GR0323"],"award-info":[{"award-number":["S2011GR0323"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["08410701800"],"award-info":[{"award-number":["08410701800"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCI-92212"],"award-info":[{"award-number":["CCI-92212"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCL-99636"],"award-info":[{"award-number":["CCL-99636"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CCM 104888"],"award-info":[{"award-number":["CCM 104888"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>50\u2009kDa chitosan was conjugated with folate, a specific tissue\u2010targeting ligand. Nanoparticles such as chitosan\u2010DNA and folate\u2010chitosan\u2010DNA were prepared by coacervation process. The hydrodynamic intravenous injection of nanoparticles was performed in the right posterior paw in normal and arthritic rats. Our results demonstrated that the fluorescence intensity of DsRed detected was 5 to 12 times more in the right soleus muscle and in the right gastro muscle than other tissue sections. <jats:italic>\u03b2<\/jats:italic>\u2010galactosidase gene expression with X\u2010gal substrate and folate\u2010chitosan\u2010plasmid nanoparticles showed best coloration in the soleus muscle. Treated arthritic animals also showed a significant decrease in paw swelling and IL\u20101<jats:italic>\u03b2<\/jats:italic> and PGE<jats:sub>2<\/jats:sub> concentration in serum compared to untreated rats. This study demonstrated that a nonviral gene therapeutic approach using hydrodynamic delivery could help transfect more efficiently folate\u2010chitosan\u2010DNA nanoparticles <jats:italic>in vitro\/in vivo<\/jats:italic> and could decrease inflammation in arthritic rats.<\/jats:p>","DOI":"10.1155\/2011\/148763","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T06:41:24Z","timestamp":1293604884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hydrodynamic Delivery of Chitosan\u2010Folate\u2010DNA Nanoparticles in Rats with Adjuvant\u2010Induced Arthritis"],"prefix":"10.1155","volume":"2011","author":[{"given":"Qin","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Covi","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise M.","family":"Winnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Benderdour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,28]]},"reference":[{"key":"e_1_2_6_1_2","first-page":"105","article-title":"Two decades of clinical gene therapy\u2014success is finally mounting","volume":"9","author":"Herzog R. W.","year":"2010","journal-title":"Discovery Medicine"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr800409e"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.09.004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/156652309790031111"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-009-9355-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950017734"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300947"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.206"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2009.133"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.05.005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737989"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215528"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2474"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.159.1.126"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050601"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05159.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10405"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.01.010"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.1983.070280607"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200500018"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.12.036"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.07.699"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.05.004"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.09.016"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90442-7"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.07.699"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(00)00361-8"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.04.029"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.09.020"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300304"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000118404.66106.E8"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302210"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(99)00062-9"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.02.003"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2006.465"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00785.x"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2011\/148763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2011\/148763.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2011\/148763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T10:46:10Z","timestamp":1720089970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2011\/148763"}},"subtitle":[],"editor":[{"given":"Oreste","family":"Gualillo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2010,12,28]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1155\/2011\/148763"],"URL":"https:\/\/doi.org\/10.1155\/2011\/148763","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,28]]},"assertion":[{"value":"2010-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"148763"}}