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Candidates for pancreatic cancer surveillance are those with a risk pancreatic cancer estimated to be &gt;10-fold that of the normal population. Screening for pancreatic cancer in high-risk individuals is typically performed by endoscopic ultrasound and should begin at least 10 years prior to the age of the youngest affected relative. Disease states known to be associated with increased risk of hepatocellular cancer include hereditary hemochromatosis, autoimmune hepatitis, porphyria, and<jats:italic>\u03b1<\/jats:italic>1-antitrypsin deficiency, with relative risks as high as 36-fold. Although much less is known about hereditary bile-duct cancers, Muir-Torre syndrome and bile salt export pump deficiency are diseases whose association with hereditary carcinogenesis is under investigation.<\/jats:p>","DOI":"10.1155\/2011\/154673","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T22:01:24Z","timestamp":1309298484000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Hereditary Pancreatic and Hepatobiliary Cancers"],"prefix":"10.1155","volume":"2011","author":[{"given":"Ashraf","family":"Haddad","sequence":"first","affiliation":[{"name":"Department of Surgery, Saint Agnes Hospital, Baltimore, MD 21229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopal C.","family":"Kowdley","sequence":"additional","affiliation":[{"name":"Department of Surgery, Saint Agnes Hospital, Baltimore, MD 21229, 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