{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T05:27:12Z","timestamp":1648531632776},"reference-count":28,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T00:00:00Z","timestamp":1298160000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Bioinformatics"],"published-print":{"date-parts":[[2011,2,20]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Delivery of full doses of adjuvant chemotherapy on schedule is key to optimal breast cancer outcomes. Neutropenia is a serious complication of chemotherapy and a common barrier to this goal, leading to dose reductions or delays in treatment. While past research has observed correlations between complete blood count data and neutropenic events, a reliable method of classifying breast cancer patients into low- and high-risk groups remains elusive. <jats:italic>Patients and Methods<\/jats:italic>. Thirty-five patients receiving adjuvant chemotherapy for early-stage breast cancer under the care of a single oncologist are examined in this study. FOS-3NN stratifies patient risk based on complete blood count data after the first cycle of treatment. All classifications are independent of breast cancer subtype and clinical markers, with risk level determined by the kinetics of patient blood count response to the first cycle of treatment. <jats:italic>Results<\/jats:italic>. In an independent test set of patients unseen by FOS-3NN, 19 out of 21 patients were correctly classified (Fisher\u2019s exact test probability <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>00023<\/mml:mn><\/mml:math> [2 tailed], Matthews\u2019 correlation coefficient +0.83). <jats:italic>Conclusions<\/jats:italic>. We have developed a model that accurately predicts neutropenic events in a population treated with adjuvant chemotherapy in the first cycle of a 6-cycle treatment.<\/jats:p>","DOI":"10.1155\/2011\/172615","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T21:01:10Z","timestamp":1329771670000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Neutropenia Prediction Based on First-Cycle Blood Counts Using a FOS-3NN Classifier"],"prefix":"10.1155","volume":"2011","author":[{"given":"Elize A.","family":"Shirdel","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, Queen\u2019s University, Kingston, ON, Canada K7L 3N6"},{"name":"Division of Signaling Biology, IBM Life Sciences Discovery Centre, Toronto Medical Discovery Tower, 9-305, 101 College Street, Toronto, Ontario, Canada M5G 1L7"}]},{"given":"Michael J.","family":"Korenberg","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Queen\u2019s University, Kingston, ON, Canada K7L 3N6"}]},{"given":"Yolanda","family":"Madarnas","sequence":"additional","affiliation":[{"name":"Departments of Oncology, Medicine, Pharmacology and Toxicology, Queen\u2019s University, Kingston, ON, Canada K7L 5P9"}]}],"member":"98","reference":[{"issue":"16","key":"3","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/jnci\/90.16.1205","volume":"90","year":"1998","journal-title":"Journal of the National Cancer Institute"},{"issue":"11","key":"9","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1200\/JCO.1984.2.11.1281","volume":"2","year":"1984","journal-title":"Journal of Clinical Oncology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504063321401"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00222-6"},{"key":"5","first-page":"S11","volume":"36, supplement 1","year":"2000","journal-title":"European Journal of 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