{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T08:32:11Z","timestamp":1719563531623},"reference-count":37,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae. The animals received either 10\u2009<jats:italic>\u03bc<\/jats:italic>L of saline or a<jats:italic>S. pneumoniae<\/jats:italic>suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7\u2009mg\/kg\/1\u2009day; placebo with dexamethasone 0.2\u2009mg\/kg\/7\u2009days; meningitis groups: dexamethasone 0.7\u2009mg\/kg\/1\u2009day and dexamethasone 0.2\u2009mg\/kg\/7\u2009days. Ten days after induction we evaluated memory and oxidative stress parameters in hippocampus and cortex. In the step-down inhibitory avoidance task, we observed memory impairment in the meningitis group with dexamethasone 0.2\u2009mg\/kg\/7\u2009days. The lipid peroxidation was increased in hippocampus in the meningitis groups with dexamethasone and in cortex only in the meningitis group with dexamethasone 0.2\u2009mg\/kg\/7\u2009days. The protein carbonyl was increased in hippocampus in the meningitis groups with dexamethasone and in cortex in the meningitis groups with and without dexamethasone. There was a decrease in the proteins integrity in hippocampus in all groups receiving treatment with dexamethasone and in cortex in all groups with dexamethasone (0.7\u2009mg\/kg\/1\u2009day). The mitochondrial superoxide was increased in the hippocampus and cortex in the meningitis group with dexamethasone 0.2\u2009mg\/kg\/7\u2009days. Our findings demonstrate that dexamethasone reverted cognitive impairment but increased brain oxidative stress in hippocampus and cortex in Wistar rats ten days after pneumococcal meningitis induction.<\/jats:p>","DOI":"10.1155\/2011\/173035","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T21:01:26Z","timestamp":1321909286000},"page":"1-7","source":"Crossref","is-referenced-by-count":9,"title":["Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis"],"prefix":"10.1155","volume":"2011","author":[{"given":"Tatiana","family":"Barichello","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Microbiology and National Institute for Translational Medicine (INCT-TM), Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Crici\u00fama, SC, 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