{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:37Z","timestamp":1787017777353,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,10,11]],"date-time":"2010-10-11T00:00:00Z","timestamp":1286755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Company Diet\u00e9ticos Intersa S.A.","award":["2696\/SRO"],"award-info":[{"award-number":["2696\/SRO"]}]},{"DOI":"10.13039\/501100004233","name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","doi-asserted-by":"publisher","award":["2696\/SRO"],"award-info":[{"award-number":["2696\/SRO"]}],"id":[{"id":"10.13039\/501100004233","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hospital Universitario La Fe of Valencia and Consejo de Seguridad Nuclear","award":["2696\/SRO"],"award-info":[{"award-number":["2696\/SRO"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>\n                    Radioprotection with natural products may be relevant to the mitigation of ionizing radiation\u2010induced damage in mammalian systems; in this sense, propolis extracts have shown effects such as antioxidant, antitumoral, anti\u2010inflammatory, and immunostimulant. We report for the first time a cytogenetic study to evaluate the radioprotective effect,\n                    <jats:italic>in vitro<\/jats:italic>\n                    , of propolis against radiation\u2010induced chromosomal damage. Lymphocytes were cultured with increasing concentrations of ethanol extract of propolis (EEP), including 20, 40, 120, 250, 500, 750, 1000, and 2000\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and then exposed to 2 Gy\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010rays. A significant and concentration\u2010dependent decrease is observed in the frequency of chromosome aberrations in samples treated with EEP. The protection against the formation of dicentrics was concentration\u2010dependent, with a maximum protection at 120\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\u2009mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    of EEP. The observed frequency of dicentrics is described as negative exponential function, indicating that the maximum protectible fraction of dicentrics is approximately 44%. Free radical scavenging and antioxidant activities are the mechanisms that these substances use to protect cells from ionizing radiation.\n                  <\/jats:p>","DOI":"10.1155\/2011\/174853","type":"journal-article","created":{"date-parts":[[2010,10,11]],"date-time":"2010-10-11T15:32:20Z","timestamp":1286811140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Concentration\u2010Dependent Protection by Ethanol Extract of Propolis against\n                    <i>\u03b3<\/i>\n                    \u2010Ray\u2010Induced Chromosome Damage in Human Blood Lymphocytes"],"prefix":"10.1155","volume":"2011","author":[{"given":"A.","family":"Montoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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