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Ivermectin (IVM) is highly microfilaricidal but minimally macrofilaricidal. The role of albendazole (ALB) in treatment regimens is not well established though the drug has a microfilaricidal effect. The combination of DEC+ALB has a better long-term impact than IVM+ALB. Recent trials have shown that doxycycline therapy against<jats:italic>Wolbachia<\/jats:italic>, an endosymbiotic bacterium of the parasite, is capable of reducing microfilaria rates and adult worm activity. Followup studies on mass drug administration (MDA) are yet to show a complete interruption of transmission, though the infection rates are reduced to a very low level.<\/jats:p>","DOI":"10.1155\/2011\/175941","type":"journal-article","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T14:37:35Z","timestamp":1293719855000},"page":"1-12","source":"Crossref","is-referenced-by-count":21,"title":["Current Evidence on the Use of Antifilarial Agents in the Management of bancroftian Filariasis"],"prefix":"10.1155","volume":"2011","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-9031","authenticated-orcid":true,"given":"Sumadhya Deepika","family":"Fernando","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo 08, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaturaka","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"University Medical Unit, National Hospital of 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