{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:03:30Z","timestamp":1773072210581,"version":"3.50.1"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Sensors"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Multiple sensor electrodes, a supplementary electrode, a reference electrode, and signal-processing circuits were integrated on a single chip to develop a chip-shaped electrochemical sensing system. L-lactate and glucose were measured using on-chip working electrodes modified by polyion complex to immobilize lactate oxidase and glucose oxidase, respectively. Cyclic voltammetry measurements were conducted using an on-chip potentiostat. Selective and quantitative detection of glucose and L-lactate and the interference behavior were studied. Hydrogen peroxide generated by enzymatic reactions was detected by an increase in anodic oxidation current. Reaction currents at +0.7\u2009V versus Ag\/AgCl were used to obtain calibration plots. The measured dynamic ranges for L-lactate and glucose were 0.2\u20131.0\u2009mM and 2.0\u20138.0\u2009mM, respectively. The sensitivities were 65\u2009nA\/mM and 15\u2009nA\/mM, respectively, using a working electrode of 0.5\u2009mm<jats:sup>2<\/jats:sup>. The 3<jats:italic>\u03c3<\/jats:italic>detection limit was 0.19\u2009mM and 1.1\u2009mM, respectively. We have achieved multiple biomaterial detections on a circuit-equipped single chip. This integrated electrochemical sensor chip could be the best candidate for realizing point-of-care testing due to its portability and potential for mass production.<\/jats:p>","DOI":"10.1155\/2011\/190284","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T19:14:56Z","timestamp":1308338096000},"page":"1-7","source":"Crossref","is-referenced-by-count":9,"title":["Smart Integrated Sensor for Multiple Detections of Glucose and L-Lactate Using On-Chip Electrochemical System"],"prefix":"10.1155","volume":"2011","author":[{"given":"Tomoyuki","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Electronic and Information Engineering, Toyohashi University of Technology, C3-601, 1-1 Hibarigaoka, Tenpaku, Toyohashi, Aichi, 441-8580, Japan"},{"name":"New Product Development Department, Hioki E. E. 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