{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:30:20Z","timestamp":1774459820958,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,2]],"date-time":"2011-06-02T00:00:00Z","timestamp":1306972800000},"content-version":"vor","delay-in-days":152,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["10772751"],"award-info":[{"award-number":["10772751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012150","name":"Shanghai Leading Academic Discipline Project","doi-asserted-by":"crossref","award":["10772751"],"award-info":[{"award-number":["10772751"]}],"id":[{"id":"10.13039\/501100012150","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Mathematics"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled.<\/jats:p>","DOI":"10.1155\/2011\/190371","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T11:26:14Z","timestamp":1307100374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the  \u201cVascular Normalization Window\u201d with Antiangiogenic Therapy"],"prefix":"10.1155","volume":"2011","author":[{"given":"Jie","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-feng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-xiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,6,2]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111182852108"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104819"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603\u2010685"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0794-58"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc704"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0297\u2010177"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553000601002324"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201006\u20104102"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/bulm.2002.0293"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010003\u20100491\u20101"},{"key":"e_1_2_6_11_2","first-page":"272","article-title":"2D numerical simulation of effect of antiangiogenic factors Angiostatin and Endostatin on tumor-induced angiogenesis","volume":"21","author":"Gaiping Z.","year":"2006","journal-title":"Journal of Medical Biomechanics"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.01.009"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20101716.1986.tb07908.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2005.08.005"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201004\u20100074"},{"key":"e_1_2_6_16_2","first-page":"125","article-title":"Research on the effect of microenvironment of tumor blood perfusion under anti-angiogenesis therapy","volume":"3","author":"Jinfeng C.","year":"2010","journal-title":"Progress in Biomedical Engineering"},{"key":"e_1_2_6_17_2","first-page":"2641","article-title":"Determinants of tumor blood flow: a review","volume":"48","author":"Jain R. 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