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We assessed 838 ED patients with psychiatric evaluations and psychometric questionnaires: Temperament and Character Inventory, Eating Disorder Inventory-2, Beck Depression Inventory, and State-Trait Anger Expression Inventory. 19.5% of ED patients were found to suffer from comorbid MD and 48.7% reported clinically significant depressive symptomatology: patients with Anorexia Binge-Purging and Bulimia Nervosa were more likely to be diagnosed with MD. Irritable mood was found in the 73% of patients with MD. High Harm Avoidance (HA) and low Self-Directedness (SD) predicted MD independently of severity of the ED symptomatology, several clinical variables, and ED diagnosis. Assessing both personality and depressive symptoms could be useful to provide effective treatments. Longitudinal studies are needed to investigate the pathogenetic role of HA and SD for ED and MD.<\/jats:p>","DOI":"10.1155\/2011\/194732","type":"journal-article","created":{"date-parts":[[2011,10,2]],"date-time":"2011-10-02T19:02:02Z","timestamp":1317582122000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Eating Disorders and Major Depression: Role of Anger and Personality"],"prefix":"10.1155","volume":"2011","author":[{"given":"Abbate-Daga","family":"Giovanni","sequence":"first","affiliation":[{"name":"Eating Disorders Program, Section of Psychiatry, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gramaglia","family":"Carla","sequence":"additional","affiliation":[{"name":"Eating Disorders Program, Section of Psychiatry, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, 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