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SSc ILD pathogenesis may share some common mechanisms with other fibrotic lung diseases, in which dysregulation of lung epithelium can contribute to pathologic fibrosis via recruitment or in situ generation and activation of fibroblasts. TGF<jats:italic>\u03b2<\/jats:italic>, a master regulator of fibrosis, is tightly regulated in the lung by the integrin<jats:italic>\u03b1<\/jats:italic>v<jats:italic>\u03b2<\/jats:italic>6, which is expressed at low levels on healthy alveolar epithelial cells but is highly induced in the setting of lung injury or fibrosis. Here we discuss the biology of<jats:italic>\u03b1<\/jats:italic>v<jats:italic>\u03b2<\/jats:italic>6 and present this integrin as a potentially attractive target for inhibition in the setting of SSc ILD.<\/jats:p>","DOI":"10.1155\/2011\/208219","type":"journal-article","created":{"date-parts":[[2011,10,16]],"date-time":"2011-10-16T19:00:24Z","timestamp":1318791624000},"page":"1-7","source":"Crossref","is-referenced-by-count":28,"title":["Blocking TGF<i>\u03b2<\/i>via Inhibition of the<i>\u03b1<\/i>v<i>\u03b2<\/i>6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease"],"prefix":"10.1155","volume":"2011","author":[{"given":"Tamiko R.","family":"Katsumoto","sequence":"first","affiliation":[{"name":"Department of Medicine, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, CA 94143, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelia 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