{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:42:17Z","timestamp":1753886537859,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"vor","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Accumulating evidence has shown the adverse effect of long\u2010term hyperaldosteronism on cardiovascular morbidity that is independent of blood pressure. However, the diagnosis of primary aldosteronism (PA) remains a challenge for patients who present with subtle or atypical features or have chronic kidney disease (CKD). SPECT\/CT has proven valuable in the diagnosis of a number of conditions. The aim of this study was to determine the usefulness of I\u2010131 NP\u201059 SPECT\/CT in patients with atypical presentations of PA and in those with CKD. The records of 15 patients with PA were retrospectively analyzed. NP\u201059 SPECT\/CT was able to identify adrenal lesion(s) in CKD patients with suspected PA. Patients using NP\u201059 SPECT\/CT imaging, compared with those not performing this procedure, significantly featured nearly normal serum potassium levels, normal aldosterone\u2010renin ratio, and smaller adrenal size on CT and pathological examination and tended to feature stage 1 hypertension and non\u2010suppressed plasma renin activity. These findings show that noninvasive NP\u201059 SPECT\/CT is a useful tool for diagnosis in patients with subclinical or atypical features of PA and those with CKD.<\/jats:p>","DOI":"10.1155\/2011\/209787","type":"journal-article","created":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T19:32:57Z","timestamp":1302204777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostic Value of I\u2010131 NP\u201059 SPECT\/CT Scintigraphy in Patients with Subclinical or Atypical Features of Primary Aldosteronism"],"prefix":"10.1155","volume":"2011","author":[{"given":"Yi-Chun","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chieh","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Kuo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jainn-Shiun","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-En","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Jer","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuh-Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,4,7]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60834-X"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410279"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510305"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033263"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0151"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0279"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2005.02.007"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2008.01.005"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812173392507"},{"key":"e_1_2_8_11_2","first-page":"43","article-title":"Limited significance of asymmetric adrenal visualization on dexamethasone-suppression scintigraphy","volume":"26","author":"Gross M. 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