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All these <jats:italic>in vitro<\/jats:italic> antioxidant activities were concentration dependent, which were compared with standard antioxidants such as BHT, <jats:italic>\u03b1<\/jats:italic>\u2010tocopherol. The hepatoprotective potential of <jats:italic>Podophyllum hexandrum<\/jats:italic> extract was also evaluated in male Wistar rats against carbon tetrachloride\u2010 (CCl<jats:sub>4<\/jats:sub>\u2010) induced liver damage. Pretreated rats were given ethyl acetate extract at 20, 30, and 50\u2009mg\/kg dose prior to CCl<jats:sub>4<\/jats:sub> administration (1\u2009mL\/kg, 1:1 in olive oil). Rats pretreated with <jats:italic>P. hexandrum<\/jats:italic> extract remarkably prevented the elevation of serum AST, ALT, LDH, and liver lipid peroxides in CCl<jats:sub>4<\/jats:sub>\u2010treated rats. Hepatic glutathione levels were significantly increased by the treatment with the extract in all the experimental groups. The extract at the tested doses also restored the levels of liver homogenate enzymes (glutathione peroxidase, glutathione reductase, superoxide dismutase, and glutathione\u2010S\u2010transferase) significantly. This study suggests that ethyl acetate extract of <jats:italic>P. hexandrum<\/jats:italic> has a liver\u2010protective effect against \nCCl<jats:sub>4<\/jats:sub>\u2010induced hepatotoxicity and possess <jats:italic>in vitro<\/jats:italic> antioxidant activities.<\/jats:p>","DOI":"10.1155\/2011\/238020","type":"journal-article","created":{"date-parts":[[2011,1,9]],"date-time":"2011-01-09T19:37:53Z","timestamp":1294601873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Antioxidant and Protective Effect of Ethyl Acetate Extract of <i>Podophyllum hexandrum<\/i> Rhizome on Carbon Tetrachloride Induced Rat Liver Injury"],"prefix":"10.1155","volume":"2011","author":[{"given":"Showkat Ahmad","family":"Ganie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehtishamul","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Masood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohmmad Afzal","family":"Zargar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,9]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.3109\/10715769309111598"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11746-998-0032-9"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02075-4"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.003"},{"key":"e_1_2_7_5_2","first-page":"196","article-title":"In vitro and in vivo evaluation of free radical scavenging potential of ethanolic extract of Podophyllum hexandrum","volume":"4","author":"Ganie S. 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