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In this paper we will review the basic physiology of calcium homeostasis and then consider genetic associations as well as common etiologies and presentations of primary hyperparathyroidism. We will consider emerging trends in detection and measurement of parathyroid hormone as well as available imaging modalities for the parathyroid glands. Surgical indications and approach will be reviewed as well as medical management of primary hyperparathyroidism with bisphosphonates and calcimimetics.<\/jats:p>","DOI":"10.1155\/2011\/251410","type":"journal-article","created":{"date-parts":[[2011,6,3]],"date-time":"2011-06-03T11:26:04Z","timestamp":1307100364000},"page":"1-8","source":"Crossref","is-referenced-by-count":66,"title":["Primary Hyperparathyroidism: An Overview"],"prefix":"10.1155","volume":"2011","author":[{"given":"Jessica","family":"MacKenzie-Feder","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 1M9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sirrs","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, BC, Canada V5Z 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