{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:32:45Z","timestamp":1791099165916,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T00:00:00Z","timestamp":1291593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Preeclampsia and preterm delivery are important potential complications in pregnancy and represent the leading causes for maternal and perinatal morbidity and mortality. The mechanisms underlying both diseases remain unknown, thus available treatments (beta2\u2010stimulants and magnesium sulfate) are essentially symptomatic. Both molecules have molecular weights less than 5\u20138\u2009kDa, cross the placental barrier, and thus exert their effects on the fetus. The fetus produces peptides that are highly vasoactive and uterotonic and increase in response to maternal stress and with continued development. Fetal peptides are also small molecules that inevitably leak across into the maternal circulation. Aminopeptidases such as placental leucine aminopeptidase (P\u2010LAP) and aminopeptidase A (APA) are large molecules that do not cross the placental barrier. We have shown that APA acts as an antihypertensive agent in the pregnant spontaneously hypertensive rat by degrading vasoactive peptides and as a result returns the animal to a normotensive state. P\u2010LAP also acts as an antiuterotonic agent by degrading uterotonic peptides and thus prolongs gestation in the pregnant mouse. Given the ever increasing worldwide incidences of preeclampsia and preterm labor, it is imperative that new agents be developed to safely prolong gestation. We believe that the use of aminopeptidases hold promise in this regard.<\/jats:p>","DOI":"10.1155\/2011\/286947","type":"journal-article","created":{"date-parts":[[2010,12,6]],"date-time":"2010-12-06T19:35:27Z","timestamp":1291664127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Placental Leucine Aminopeptidase\u2010 and Aminopeptidase A\u2010Deficient Mice Offer Insight concerning the Mechanisms Underlying Preterm Labor and Preeclampsia"],"prefix":"10.1155","volume":"2011","author":[{"given":"Shigehiko","family":"Mizutani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,6]]},"reference":[{"key":"e_1_2_12_1_2","first-page":"449","article-title":"Factors affecting angiotensin II concentrations in the human infant at birth","volume":"52","author":"Broughton-Pipkin F.","year":"1977","journal-title":"Clinical Science and Molecular Medicine"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15276.x"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(89)90060-1"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/234352a0"},{"key":"e_1_2_12_5_2","first-page":"173","article-title":"Purification and properties of oxytocinase, a metalloenzyme","volume":"2","author":"Sakura H.","year":"1981","journal-title":"Biochemical International"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1210503"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90007-J"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2744(81)90240-0"},{"key":"e_1_2_12_9_2","first-page":"135","article-title":"In vitro degradation of angiotensin II (A-II) by human placental subcellular fractions, pregnancy sera and purified placental aminopeptidases","volume":"110","author":"Mizutani S.","year":"1985","journal-title":"Acta Endocrinologica"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1517\/17530050903074556"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111726"},{"key":"e_1_2_12_12_2","first-page":"859","volume-title":"Maternal-Fetal Medicine","author":"Roberts J. 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