{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:40:24Z","timestamp":1728175224694},"reference-count":33,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Multiple Sclerosis International"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Recent studies have shown that OCT-measured retinal nerve fiber layer (RNFL) values may represent a marker for axonal damage in the anterior visual pathway of optic neuritis (ON) and multiple sclerosis (MS) patients. The goal of this study was to determine the link between RNFL values and initial magnetic resonance imaging (MRI) evidence of central nervous system (CNS) inflammation in patients with acute ON.<jats:italic>Methods<\/jats:italic>. Fifty patients who experienced ON as a clinically isolated syndrome (CIS) were followed for a mean period of 34 months with OCT testing. RNFL values in affected (ON) eyes and clinically unaffected (non-ON) eyes were compared between patients with MRI evidence of white matter lesions and those with normal baseline MRI findings, over a two year period.<jats:italic>Findings<\/jats:italic>. Twenty-one patients (42%) developed clinically definite MS (CDMS) during the study. After two years, temporal RNFL values were thinner (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.07<\/mml:mn><\/mml:math>) in ON patients with MRI lesions at baseline, but the results were not significant.<jats:italic>Conclusions<\/jats:italic>. There is no association between RNFL values and baseline MRI status in ON patients at risk for future CDMS over a two year period.<\/jats:p>","DOI":"10.1155\/2011\/289785","type":"journal-article","created":{"date-parts":[[2011,5,29]],"date-time":"2011-05-29T15:34:43Z","timestamp":1306683283000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Association between Retinal Nerve Fiber Layer Thickness and Initial Magnetic Resonance Imaging Findings in Patients with Acute Optic Neuritis"],"prefix":"10.1155","volume":"2011","author":[{"given":"Fiona","family":"Costello","sequence":"first","affiliation":[{"name":"Departments of Clinical Neurosciences and Surgery, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada T2N 2T9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Hodge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The University of Western Ontario, London, ON, Canada N6A 4V2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. Irene","family":"Pan","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC, H3a, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11919-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70071-5"},{"issue":"9","key":"3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM199202273260901","volume":"326","year":"1992","journal-title":"The New England Journal of Medicine"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1212\/WNL.49.5.1404","volume":"49","year":"1997","journal-title":"Neurology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.7.944"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.6.727"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0950"},{"issue":"11","key":"8","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1212\/WNL.54.11.2039","volume":"54","year":"2000","journal-title":"Neurology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431301"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04725-5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237641.33768.8d"},{"issue":"11","key":"12","first-page":"2520","volume":"40","year":"1999","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20575"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.040"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2006.00724.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20851"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.11.051"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1177\/1352458507076952"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260612.51849.ed"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295995.46586.ae"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000294876.49861.dc"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm285"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.10.020"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508090221"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508091367"},{"issue":"5035","key":"26","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1957169","volume":"254","year":"1991","journal-title":"Science"},{"issue":"5","key":"29","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1001\/archopht.1995.01100050054031","volume":"113","year":"1995","journal-title":"Archives of Ophthalmology"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20703"},{"issue":"2","key":"31","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1111\/j.1552-6569.2010.00468.x","volume":"21","year":"2011","journal-title":"The Journal of Neuroimaging"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.04.010"},{"issue":"4","key":"33","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1017\/S031716710000915X","volume":"35","year":"2008","journal-title":"Canadian Journal of Neurological Sciences"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.265"},{"issue":"3","key":"35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ana.410130302","volume":"13","year":"1983","journal-title":"Annals of Neurology"}],"container-title":["Multiple Sclerosis International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/msi\/2011\/289785.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/msi\/2011\/289785.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/msi\/2011\/289785.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T20:56:34Z","timestamp":1497905794000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/msi\/2011\/289785\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":33,"alternative-id":["289785","289785"],"URL":"https:\/\/doi.org\/10.1155\/2011\/289785","relation":{},"ISSN":["2090-2654","2090-2662"],"issn-type":[{"value":"2090-2654","type":"print"},{"value":"2090-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}