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(VP), known as \u201cValeriana del monte\u201d, and used in Mesoamerican folk medicine to treat sleep disorders. This study examines the pharmacological effects of the hydroalcoholic extract of the dry rhizome using the open field, rota rod, elevated plus\u2010maze (EPM), forced swimming (FST), strychnine\u2010 and pentobarbital\u2010induced sleeping time, PTZ\u2010induced seizures, and the inhibitory avoidance tests. VP did not show any protective effect against PTZ\u2010induced convulsions. In the EPM, exhibited an anxiolytic\u2010like effect through the effective enhancement of the entries (38.5%) and time spent (44.7%) in the open arms, when compared with control group. Time spent and the numbers of entrances into the enclosed arms were decreased, similar to those effects observed with diazepam. In the FST, acute treatment with VP, produced a dose\u2010dependent decrease in immobility time, similarly to imipramine. VP also produced a significant dose\u2010dependent decrease in the latency of sleeping time, while producing an increase in total duration of sleep; influenced memory consolidation of the animals only at lower doses, unlike those that produced anti\u2010depressant and anxiolytic effects. In summary, the results suggest that VP presents several psychopharmacological activities, including anxiolytic, antidepressant, and hypno\u2010sedative effects.<\/jats:p>","DOI":"10.1155\/2011\/312320","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T21:41:17Z","timestamp":1309470077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of Behavioral and Pharmacological Effects of Hydroalcoholic Extract of <i>Valeriana prionophylla<\/i> Standl. from Guatemala"],"prefix":"10.1155","volume":"2011","author":[{"given":"Iandra","family":"Holzmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdir","family":"Cechinel Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ticiana C.","family":"Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"C\u00e1ceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Vicente","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sully M.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Maria","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,30]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103999(01)00285\u20109"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1389\u20109457(04)90004\u20104"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.04.010"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1590\/S0102-695X2006000500016","article-title":"Treatment of drug dependence with Brazilian herbal medicines","volume":"16","author":"Carlini E. 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