{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:09:25Z","timestamp":1770268165039,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Tokyo Metropolitan Hospitals Group","award":["2006-2007"],"award-info":[{"award-number":["2006-2007"]}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["2006-2007"],"award-info":[{"award-number":["2006-2007"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the usefulness of one of IGRAs, QuantiFERON-TB Gold (QFT-G), in human immunodeficiency virus- (HIV- ) infected patients with various<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>CD<\/mml:mtext><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:math>T cell counts.<jats:italic>Methods<\/jats:italic>. The QFT-G assay was performed using QFT-G kits among 107 HIV-infected patients including 9 cases with active tuberculosis (TB).<jats:italic>Results<\/jats:italic>. In HIV-infected patients with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>CD<\/mml:mtext><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><mml:mo>&gt;<\/mml:mo><mml:mrow><mml:mrow><mml:mtext>5<\/mml:mtext><mml:mn>0<\/mml:mn><\/mml:mrow><mml:mo>\/<\/mml:mo><mml:mrow><mml:mi>\u03bc<\/mml:mi><mml:mtext>L<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>, QFT-G positive rate for active TB patients was 5\/6 (sensitivity<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>=<\/mml:mo><mml:mn>83<\/mml:mn><mml:mi>%<\/mml:mi><\/mml:math>), and that for those without active disease was 1\/69 (specificity<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>=<\/mml:mo><mml:mn>99<\/mml:mn><mml:mi>%<\/mml:mi><\/mml:math>). The frequency of indeterminate QFT-G test was significantly higher in those with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>CD<\/mml:mtext><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:math>less than<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mrow><mml:mtext>5<\/mml:mtext><mml:mn>0<\/mml:mn><\/mml:mrow><mml:mo>\/<\/mml:mo><mml:mrow><mml:mi>\u03bc<\/mml:mi><mml:mtext>L<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.0001<\/mml:mn><\/mml:math>). At the same time there was a proportional relationship between<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>CD<\/mml:mtext><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:math>and interferon-gamma response to mitogen (positive control) in QFT-G test (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>.0001<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Our data suggested that QFT-G had high sensitivity and specificity in HIV-infected populations with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>CD<\/mml:mtext><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:math>greater than<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mrow><mml:mtext>5<\/mml:mtext><mml:mn>0<\/mml:mn><\/mml:mrow><mml:mo>\/<\/mml:mo><mml:mrow><mml:mi>\u03bc<\/mml:mi><mml:mtext>L<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>. However, QFT-G did not perform well in HIV-positive patients with<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mtext>CD<\/mml:mtext><mml:msup><mml:mn>4<\/mml:mn><mml:mo>+<\/mml:mo><\/mml:msup><\/mml:math>less than<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mrow><mml:mtext>5<\/mml:mtext><mml:mn>0<\/mml:mn><\/mml:mrow><mml:mo>\/<\/mml:mo><mml:mrow><mml:mi>\u03bc<\/mml:mi><mml:mtext>L<\/mml:mtext><\/mml:mrow><\/mml:mrow><\/mml:math>.<\/jats:p>","DOI":"10.1155\/2011\/325295","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T17:34:07Z","timestamp":1281461647000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Performance of a Whole-Blood Interferon-Gamma Release Assay with<i>Mycobacterium<\/i>RD1-Specific Antigens among HIV-Infected Persons"],"prefix":"10.1155","volume":"2011","author":[{"given":"Akira","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Tokyo Metropolitan Tama Medical Center, 2-8-29 Musashidai, Fuchu-shi, Tokyo 183-8524, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ajisawa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 18-22-3 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Harada","sequence":"additional","affiliation":[{"name":"The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazue","family":"Higuchi","sequence":"additional","affiliation":[{"name":"The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Mori","sequence":"additional","affiliation":[{"name":"The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"rr-20","key":"1","first-page":"1","volume":"47","year":"1998","journal-title":"MMWR. 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