{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T13:03:27Z","timestamp":1743685407981},"reference-count":36,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T00:00:00Z","timestamp":1300320000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy"],"published-print":{"date-parts":[[2011,3,17]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The risks of occupational asthma (OA) from antibiotics are uncertain. We report 4 new cases and a systematic review of the literature. <jats:italic>Methods<\/jats:italic>. Cases were identified through a specialist clinic, each underwent specific provocation testing (SPT). We subsequently reviewed the published literature. <jats:italic>Results<\/jats:italic>. The patients were employed in the manufacture of antibiotics; penicillins were implicated in three cases, in the fourth erythromycin, not previously reported to cause OA. In two, there was evidence of specific IgE sensitisation. At SPT each developed a late asthmatic reaction and increased bronchial hyperresponsiveness. 36 case reports have been previously published, 26 (citing penicillins or cephalosporins). Seven cross-sectional workplace-based surveys found prevalences of 5\u20138%. <jats:italic>Conclusions<\/jats:italic>. OA in antibiotic manufacturers may be more common than is generally recognised. Its pathogenesis remains unclear; immunological tests are of uncertain value and potential cases require confirmation with SPT. Further study of its frequency, mechanisms, and diagnosis is required.<\/jats:p>","DOI":"10.1155\/2011\/365683","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T19:33:11Z","timestamp":1300390391000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Occupational Asthma in Antibiotic Manufacturing Workers: Case Reports and Systematic Review"],"prefix":"10.1155","volume":"2011","author":[{"given":"Sara","family":"D\u00edaz Angulo","sequence":"first","affiliation":[{"name":"Centro Medico de Asturias, Avendia Jos\u00e9 Mar\u00eda Richard, Oviedo, 33193 Asturias, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Szram","sequence":"additional","affiliation":[{"name":"Department of Occupational & Environmental Medicine, National Heart & Lung Institute (Imperial College) and Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Occupational & Environmental Medicine, National Heart & Lung Institute (Imperial College) and Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Occupational & Environmental Medicine, National Heart & Lung Institute (Imperial College) and Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cullinan","sequence":"additional","affiliation":[{"name":"Department of Occupational & Environmental Medicine, National Heart & Lung Institute (Imperial College) and Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","first-page":"555","volume-title":"Other chemical substances causing occupational asthma","year":"2006"},{"issue":"6","key":"2","first-page":"488","volume":"72","year":"1981","journal-title":"Medicina del Lavoro"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0091-6749(73)90079-1","volume":"52","year":"1973","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/thx.43.5.371","volume":"43","year":"1988","journal-title":"Thorax"},{"key":"5","first-page":"1","volume":"128, supplement","year":"1983","journal-title":"European Journal of Respiratory Diseases"},{"issue":"4","key":"7","first-page":"340","volume":"8","year":"1953","journal-title":"A. 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