{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:55:02Z","timestamp":1753883702093,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T00:00:00Z","timestamp":1316476800000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>At least two laboratories have independently reported the synthesis of benzofuroindole compounds having potential therapeutic implications in many disease states including those that involve smooth muscle hyperactivity. Through a series of<jats:italic>in vitro<\/jats:italic>screenings, they demonstrated the efficacy (and selectivity) of these compounds to potentiate large conductance calcium\u2010 (Ca<jats:sup>2+<\/jats:sup>\u2010) activated K<jats:sup>+<\/jats:sup>(BK<jats:sub>Ca<\/jats:sub>) channels, by far, the most characterized of all Ca<jats:sup>2+<\/jats:sup>\u2010dependent K<jats:sup>+<\/jats:sup>channels. Interestingly, promising benzofuroindole derivatives such as compound 7 (10<jats:italic>H<\/jats:italic>\u2010benzo[4,5]furo[3,2\u2010<jats:italic>b<\/jats:italic>]indole) and compound 22 (4\u2010chloro\u20107\u2010trifluoromethyl\u201010<jats:italic>H<\/jats:italic>\u2010benzo[4,5]furo[3,2\u2010<jats:italic>b<\/jats:italic>]indole\u20101\u2010carboxylic acid) both exhibited high bladder (versus aorta) selectivity, making them attractive alternative treatments for bladder overactivity. In recent reports, compound 22 (LDD175 or TBIC) also showed inhibition of ileum and uterine contractions, indicating multiple target tissues, which is not surprising as BK<jats:sub>Ca<\/jats:sub>channels are ubiquitously expressed in the animal and human tissues. In this paper, the authors discuss the value of benzofuroindole compounds and the challenges that need to be overcome if they were considered as smooth muscle relaxants.<\/jats:p>","DOI":"10.1155\/2011\/389056","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T19:23:39Z","timestamp":1316546619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["On Benzofuroindole Analogues as Smooth Muscle Relaxants"],"prefix":"10.1155","volume":"2011","author":[{"given":"Ike","family":"dela Pe\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hoon","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,20]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1997.tb11002.x"},{"key":"e_1_2_8_2_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(24)01321-8","article-title":"Calcium movements, distribution, and functions in smooth muscle","volume":"49","author":"Karaki H.","year":"1997","journal-title":"Pharmacological Reviews"},{"volume-title":"Human Physiology: The Mechanism of Body Function","year":"2001","author":"Vander A.","key":"e_1_2_8_3_2"},{"key":"e_1_2_8_4_2","first-page":"93","volume-title":"Basic and Clinical Pharmacology","author":"Pappano A. 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