{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:59:11Z","timestamp":1791388751835,"version":"4.3.3"},"reference-count":96,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain disorders caused by defective synaptic plasticity. One of the central mechanisms responsible for opening the sensitive period is the maturation of inhibitory innervation. Many molecular and cellular events have been identified that drive this developmental process, including signaling through BDNF and IGF-1, transcriptional control by OTX2, maturation of the extracellular matrix, and GABA-regulated inhibitory synapse formation. The mechanisms through which the development of inhibitory innervation triggers and potentially closes the sensitive period may involve plasticity of inhibitory inputs or permissive regulation of excitatory synapse plasticity. Here, we discuss the current state of knowledge in the field and open questions to be addressed.<\/jats:p>","DOI":"10.1155\/2011\/391763","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T15:00:43Z","timestamp":1312297243000},"page":"1-11","source":"Crossref","is-referenced-by-count":50,"title":["The Role of GABAergic Inhibition in Ocular Dominance Plasticity"],"prefix":"10.1155","volume":"2011","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5291-4184","authenticated-orcid":true,"given":"J. Alexander","family":"Heimel","sequence":"first","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00eblle","family":"van Versendaal","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiaan N.","family":"Levelt","sequence":"additional","affiliation":[{"name":"Department of Molecular Visual Plasticity, Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2008.05.009"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1207\/S15326942DN1802_5","volume":"18","year":"2000","journal-title":"Developmental Neuropsychology"},{"key":"3","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1152\/jn.1963.26.6.1003","volume":"26","year":"1963","journal-title":"Journal of Neurophysiology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2003.02.001"},{"key":"5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1113\/jphysiol.1962.sp006837","volume":"160","year":"1962","journal-title":"The Journal of physiology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/09273970500536243"},{"issue":"961","key":"7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1098\/rstb.1977.0050","volume":"278","year":"1977","journal-title":"Philosophical Transactions of the Royal Society of London B"},{"issue":"11","key":"8","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1523\/JNEUROSCI.19-11-04388.1999","volume":"19","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960520)369:1<64::AID-CNE5>3.0.CO;2-I"},{"issue":"10","key":"10","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1523\/JNEUROSCI.21-10-03476.2001","volume":"21","year":"2001","journal-title":"Journal of Neuroscience"},{"issue":"10","key":"11","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1523\/JNEUROSCI.16-10-03274.1996","volume":"16","year":"1996","journal-title":"Journal of Neuroscience"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)90210-0"},{"issue":"10","key":"13","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1523\/JNEUROSCI.04-10-02543.1984","volume":"4","year":"1984","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"14","first-page":"432","volume":"99","year":"1979","journal-title":"Transactions of the Ophthalmological Societies of the United Kingdom"},{"issue":"5393","key":"15","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.282.5393.1504","volume":"282","year":"1998","journal-title":"Science"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072699"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.02.007"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/35004582"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81509-3"},{"issue":"22","key":"20","doi-asserted-by":"crossref","first-page":"RC40","DOI":"10.1523\/JNEUROSCI.19-22-j0003.1999","volume":"19","year":"1999","journal-title":"The Journal of Neuroscience"},{"issue":"11","key":"21","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1002\/j.1460-2075.1990.tb07564.x","volume":"9","year":"1990","journal-title":"EMBO Journal"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934836100"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000475"},{"issue":"8","key":"24","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1523\/JNEUROSCI.20-08-02926.2000","volume":"20","year":"2000","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/jphysiol.1997.sp022054","volume":"500","year":"1997","journal-title":"Journal of Physiology"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192159599"},{"issue":"1","key":"27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1152\/jn.1993.70.1.387","volume":"70","year":"1993","journal-title":"Journal of Neurophysiology"},{"issue":"7","key":"28","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1523\/JNEUROSCI.22-07-02513.2002","volume":"22","year":"2002","journal-title":"Journal of Neuroscience"},{"issue":"5","key":"29","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0896-6273(00)80401-8","volume":"19","year":"1997","journal-title":"Neuron"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091032"},{"key":"31","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1093\/cercor\/bhl117","volume":"17","year":"2007","journal-title":"Cerebral Cortex"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.054"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/nn1334"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.05.015"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/nn2008"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114362"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1038\/416636a"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-70956-7-7"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.001"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102088899"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq145"},{"issue":"3","key":"42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF01194979","volume":"21","year":"1992","journal-title":"Journal of Neurocytology"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1038\/nn1899"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1126\/science.1150516"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2233-09.2010"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1126\/science.1183962"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4384-10.2010"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.021"},{"issue":"5901","key":"49","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/301603a0","volume":"301","year":"1983","journal-title":"Nature"},{"issue":"5548","key":"50","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/260256a0","volume":"260","year":"1976","journal-title":"Nature"},{"issue":"5813","key":"51","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/291318a0","volume":"291","year":"1981","journal-title":"Nature"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5416.962"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806159105"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5025-09.2010"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1101\/lm.75304"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05333.x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1038\/nature08485"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.08.002"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp072"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.09.010"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10905"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5340-09.2010"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2182-08.2008"},{"key":"64","first-page":"21","volume":"4","year":"2010","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"1","key":"65","first-page":"1","volume":"41","year":"1980","journal-title":"Experimental Brain Research"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.10.019"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1038\/nature05079"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.036"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2979-10.2010"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.05.028"},{"issue":"2","key":"71","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrn1327","volume":"5","year":"2004","journal-title":"Nature Reviews Neuroscience"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1038\/nature04671"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.023"},{"issue":"6064","key":"74","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/320750a0","volume":"320","year":"1986","journal-title":"Nature"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00553-3"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5554-05.2006"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5298-07.2008"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3085-10.2010"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00663-3"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1067-10.2010"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1038\/nn1351"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2008.00431.x"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000710)422:4<652::AID-CNE11>3.0.CO;2-1"},{"issue":"17","key":"84","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1523\/JNEUROSCI.21-17-06791.2001","volume":"21","year":"2001","journal-title":"Journal of Neuroscience"},{"issue":"35","key":"85","doi-asserted-by":"crossref","first-page":"11142","DOI":"10.1523\/JNEUROSCI.23-35-11142.2003","volume":"23","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060342"},{"issue":"5","key":"87","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1152\/jn.1996.76.5.2896","volume":"76","year":"1996","journal-title":"Journal of Neurophysiology"},{"issue":"2","key":"88","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0896-6273(00)81097-1","volume":"22","year":"1999","journal-title":"Neuron"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1038\/nature07991"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1038\/nature08002"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1038\/73936"},{"issue":"5","key":"92","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nn.2799","volume":"14","year":"2011","journal-title":"Nature Neuroscience"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.2029"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.02.020"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.012"},{"issue":"23","key":"96","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1523\/JNEUROSCI.18-23-09896.1998","volume":"18","year":"1998","journal-title":"Journal of Neuroscience"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2011\/391763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2011\/391763.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2011\/391763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T13:52:06Z","timestamp":1560433926000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/np\/2011\/391763\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":96,"alternative-id":["391763","391763"],"URL":"https:\/\/doi.org\/10.1155\/2011\/391763","relation":{},"ISSN":["2090-5904","1687-5443"],"issn-type":[{"value":"2090-5904","type":"print"},{"value":"1687-5443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}