{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:37:36Z","timestamp":1753886256767,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T00:00:00Z","timestamp":1297209600000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Type 1 diabetic patients have increased risk of developing in\u2010stent restenosis following endovascular stenting. Underlying pathogenetic mechanisms are not fully understood partly due to the lack of a relevant animal model to study the effect(s) of long\u2010term autoimmune diabetes on development of in\u2010stent restenosis. We here describe the development of in\u2010stent restenosis in long\u2010term (~7 months) spontaneously diabetic and age\u2010matched, thymectomized, nondiabetic Diabetes Prone BioBreeding (BBDP) rats (<jats:italic>n<\/jats:italic> = 6\u20107 in each group). Diabetes was suboptimally treated with insulin and was characterized by significant hyperglycaemia, polyuria, proteinuria, and increased HbA<jats:sub>1c<\/jats:sub> levels. Stented abdominal aortas were harvested 28 days after stenting. Computerized morphometric analysis revealed significantly increased neointima formation in long\u2010term diabetic rats compared with nondiabetic controls. In conclusion, long\u2010term autoimmune diabetes in BBDP rats enhances in\u2010stent restenosis. This model can be used to study the underlying pathogenetic mechanisms of diabetes\u2010enhanced in\u2010stent restenosis as well as to test new therapeutic modalities.<\/jats:p>","DOI":"10.1155\/2011\/396734","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T19:31:19Z","timestamp":1297279879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Type 1 Diabetes Enhances In\u2010Stent Restenosis after Aortic Stenting in Diabetes\u2010Prone BB Rats"],"prefix":"10.1155","volume":"2011","author":[{"given":"Geanina","family":"Onuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik C.","family":"Groenewegen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flip A.","family":"Klatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Walther Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike","family":"Goris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton J. 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