{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:40:26Z","timestamp":1740138026046,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Our aim was to investigate the effects of IL-6 blockade on the progression of<jats:italic>Mycobacterium tuberculosis<\/jats:italic>(TB) and compare them with those of TNF-<jats:italic>\u03b1<\/jats:italic>blockade in mice.<jats:italic>Methods<\/jats:italic>. Mice were intravenously infected with TB and injected with antibodies. Survival was monitored and histological and immunological studies were carried out.<jats:italic>Results<\/jats:italic>. All anti-IL-6R Ab-treated mice and 8 of 10 control mice survived until sacrificed 224 days after TB challenge, whereas anti-TNF-<jats:italic>\u03b1<\/jats:italic>Ab-treated mice all died between 120 and 181 days. Anti-IL-6R Ab-treated mice exhibited no significant differences in TB CFU in organs, including the lungs, and no deterioration in histopathology compared to control mice at 4 weeks. In contrast, anti-TNF-<jats:italic>\u03b1<\/jats:italic>Ab-treated mice exhibited increased TB CFU and greater progression of histopathological findings in organs than control mice. Spleen cells from anti-TNF-<jats:italic>\u03b1<\/jats:italic>Ab-treated mice had decreased antigen-specific response in IFN-<jats:italic>\u03b3<\/jats:italic>release and proliferation assays. The results in anti-IL-6R Ab-treated mice suggest that spleen cell responses were decreased to a lesser degree. Similar results were obtained in IL-6 knockout (KO) mice, compared with TNF receptor 1 (TNFR1) KO and TNFR1\/IL-6 double KO (DKO) mice.<jats:italic>Conclusion<\/jats:italic>. IL-6R blockade promotes the progression of TB infection in mice far less than TNF-<jats:italic>\u03b1<\/jats:italic>blockade.<\/jats:p>","DOI":"10.1155\/2011\/404929","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T19:32:43Z","timestamp":1301513563000},"page":"1-9","source":"Crossref","is-referenced-by-count":18,"title":["Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- Antibody in Mice"],"prefix":"10.1155","volume":"2011","author":[{"given":"Masaji","family":"Okada","sequence":"first","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan"}]},{"given":"Yoko","family":"Kita","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan"}]},{"given":"Noriko","family":"Kanamaru","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan"}]},{"given":"Satomi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan"}]},{"given":"Yasushi","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd., Product Research Department, Shizuoka 412-8513, Japan"}]},{"given":"Masahiko","family":"Mihara","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd., Product Research Department, Shizuoka 412-8513, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-874X","authenticated-orcid":true,"given":"Yoshikazu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan"}]},{"given":"Yoshiyuki","family":"Ohsugi","sequence":"additional","affiliation":[{"name":"Chugai Pharmaceutical Co., Ltd., Product Research Department, Shizuoka 412-8513, Japan"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan"}]},{"given":"Mitsunori","family":"Sakatani","sequence":"additional","affiliation":[{"name":"Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka 591-8555, Japan"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05246-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432202"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432201"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068064"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60453-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.5.669"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/art.11137"},{"issue":"6","key":"9","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.4049\/jimmunol.171.6.3110","volume":"171","year":"2003","journal-title":"Journal of Immunology"},{"issue":"74","key":"10","first-page":"35","volume":"32","year":"2005","journal-title":"Journal of Rheumatology"},{"issue":"6","key":"11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/1074-7613(95)90001-2","volume":"2","year":"1995","journal-title":"Immunity"},{"volume":"68","journal-title":"Annals of the Rheumatic Diseases","year":"2009","key":"12"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01244.x"},{"issue":"11","key":"14","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/IAI.65.11.4843-4849.1997","volume":"65","year":"1997","journal-title":"Infection and Immunity"},{"issue":"3","key":"15","first-page":"361","volume":"82","year":"1994","journal-title":"Immunology"},{"issue":"1","key":"16","first-page":"22","volume":"30","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11924"},{"issue":"11","key":"18","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.4049\/jimmunol.142.11.3884","volume":"142","year":"1989","journal-title":"Journal of Immunology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.08.103"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2014-2021.2004"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9784"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1500-8"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg091"},{"issue":"6","key":"24","first-page":"1132","volume":"31","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.93"},{"issue":"5","key":"26","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.4049\/jimmunol.141.5.1543","volume":"141","year":"1988","journal-title":"Journal of Immunology"},{"issue":"7","key":"27","first-page":"1335","volume":"57","year":"1997","journal-title":"Cancer Research"},{"issue":"12","key":"28","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.4049\/jimmunol.167.12.6991","volume":"167","year":"2001","journal-title":"Journal of Immunology"},{"issue":"10","key":"29","doi-asserted-by":"crossref","first-page":"7086","DOI":"10.4049\/jimmunol.177.10.7086","volume":"177","year":"2006","journal-title":"Journal of Immunology"},{"issue":"4","key":"30","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.4049\/jimmunol.176.4.2496","volume":"176","year":"2006","journal-title":"Journal of Immunology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0505239"},{"issue":"3","key":"32","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.4049\/jimmunol.177.3.1416","volume":"177","year":"2006","journal-title":"Journal of Immunology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.9.5782-5788.2005"},{"issue":"1","key":"34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/IAI.58.1.269-271.1990","volume":"58","year":"1990","journal-title":"Infection and Immunity"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.2249"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830271215"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200418991"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.6.3322-3326.2000"},{"issue":"5","key":"39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0092-8674(89)90676-4","volume":"56","year":"1989","journal-title":"Cell"},{"issue":"7","key":"40","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.4049\/jimmunol.159.7.3595","volume":"159","year":"1997","journal-title":"Journal of Immunology"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/368339a0"},{"issue":"6","key":"42","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1128\/IAI.63.6.2262-2268.1995","volume":"63","year":"1995","journal-title":"Infection and Immunity"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1345"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00612.x"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.2012"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.057"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/nm0496-430"}],"container-title":["Clinical and Developmental Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2011\/404929.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2011\/404929.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2011\/404929.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T15:40:38Z","timestamp":1712331638000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2011\/404929\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":47,"alternative-id":["404929","404929"],"URL":"https:\/\/doi.org\/10.1155\/2011\/404929","relation":{},"ISSN":["1740-2522","1740-2530"],"issn-type":[{"type":"print","value":"1740-2522"},{"type":"electronic","value":"1740-2530"}],"subject":[],"published":{"date-parts":[[2011]]}}}