{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:43:59Z","timestamp":1773812639385,"version":"3.50.1"},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Morinaga Milk Industry Co., Ltd., Zama, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>This study was undertaken to evaluate the effect of oral administration of lactoferrin (LF) and lactoperoxidase-(LPO-)containing tablet on periodontal condition. Seventy-two individuals with chronic periodontitis were randomly assigned to take either bovine LF and LPO-containing tablets (test group,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>37<\/mml:mn><\/mml:mrow><\/mml:math>) or control tablets (control group,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>35<\/mml:mn><\/mml:mrow><\/mml:math>) every day for 12 weeks. Periodontal parameters and levels of subgingival plaque bacteria, human and bovine LF, and endotoxin in gingival crevicular fluid (GCF) were evaluated at baseline, 1 week, 4 weeks, and 12 weeks. Significant differences were observed in GCF levels of bovine LF between the test and control groups throughout the study (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>.05<\/mml:mn><\/mml:mrow><\/mml:math>). However, clinical and bacteriological parameter values proved comparable between the two groups at 1 week to 12 weeks. Therefore, the effect of oral administration of LF and LPO-containing tablets might be weak on periodontal and bacteriological profile in this study.<\/jats:p>","DOI":"10.1155\/2011\/405139","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T12:58:48Z","timestamp":1301921928000},"page":"1-9","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Orally Administered Lactoferrin and Lactoperoxidase-Containing Tablets on Clinical and Bacteriological Profiles in Chronic Periodontitis Patients"],"prefix":"10.1155","volume":"2011","author":[{"given":"Eiju","family":"Shimizu","sequence":"first","affiliation":[{"name":"Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"},{"name":"Shimizu Dental Clinic, Takasaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"},{"name":"General Dentistry and Clinical Education Unit, Niigata University Medical and Dental Hospital, 2-5274 Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Food Science & Technology Institute, Morinaga Milk Industry Co., Ltd., Zama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[{"name":"Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/annals.1996.1.1.443","volume":"1","year":"1996","journal-title":"Annals of Periodontology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291102.x"},{"issue":"1","key":"3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-0757.1997.tb00109.x","volume":"15","year":"1997","journal-title":"Periodontology 2000"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1902\/annals.2003.8.1.79","volume":"8","year":"2003","journal-title":"Annals of Periodontology"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1034\/j.1600-0757.2002.280105.x","volume":"28","year":"2002","journal-title":"Periodontology 2000"},{"issue":"3","key":"6","first-page":"252","volume":"80","year":"1995","journal-title":"Haematologica"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.1999.049"},{"key":"8","first-page":"247","volume":"10","year":"2001","journal-title":"Advances in Nutritional Research"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(98)00030-3"},{"issue":"10","key":"10","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1128\/IAI.56.10.2552-2557.1988","volume":"56","year":"1988","journal-title":"Infection and Immunity"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1399-302X.1994.tb00055.x","volume":"9","year":"1994","journal-title":"Oral Microbiology and Immunology"},{"issue":"39","key":"12","doi-asserted-by":"crossref","first-page":"30002","DOI":"10.1074\/jbc.M001518200","volume":"275","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01688-08"},{"issue":"3","key":"14","first-page":"281","volume":"51","year":"2008","journal-title":"The Japanese Journal of Conservative Dentistry"},{"key":"15","first-page":"123","volume-title":"Lactoperoxidase: structure and catalytic properties","volume":"1","year":"1991"},{"issue":"2","key":"16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/IAI.62.2.529-535.1994","volume":"62","year":"1994","journal-title":"Infection and Immunity"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1099\/0022-1317-50-1-42","volume":"50","year":"2001","journal-title":"Journal of Medical Microbiology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-010-0422-x"},{"key":"19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/00016356408993968","volume":"22","year":"1964","journal-title":"Acta Odontologica Scandinavica"},{"key":"20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","volume":"21","year":"1963","journal-title":"Acta Odontologica Scandinavica"},{"issue":"1","key":"21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","volume":"43","year":"1972","journal-title":"Journal of Periodontology"},{"issue":"2","key":"22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-051X.1993.tb00328.x","volume":"20","year":"1993","journal-title":"Journal of Clinical Periodontology"},{"issue":"1","key":"23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/JCM.36.1.157-160.1998","volume":"36","year":"1998","journal-title":"Journal of Clinical Microbiology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00832.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2008.06.001"},{"issue":"5, supplement","key":"26","first-page":"389S","volume":"20","year":"2001","journal-title":"Journal of the American College of Nutrition"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70636"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/AAC.2.1.23","volume":"2","year":"1972","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"1","key":"29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1177\/00220345840630010301","volume":"63","year":"1984","journal-title":"Journal of Dental Research"},{"issue":"4","key":"30","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/154405910608500401","volume":"85","year":"2006","journal-title":"Journal of Dental Research"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.03.007"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080350"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2009.01071.x"},{"issue":"5","key":"34","first-page":"31","volume":"14","year":"1992","journal-title":"Clinical preventive dentistry"},{"issue":"4","key":"35","first-page":"337","volume":"6","year":"2008","journal-title":"Oral Health & Preventive Dentistry"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1159\/000084800"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2006.00808.x"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-20"}],"container-title":["International Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2011\/405139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2011\/405139.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2011\/405139.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T21:35:46Z","timestamp":1592429746000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijd\/2011\/405139\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":38,"alternative-id":["405139","405139"],"URL":"https:\/\/doi.org\/10.1155\/2011\/405139","relation":{},"ISSN":["1687-8728","1687-8736"],"issn-type":[{"value":"1687-8728","type":"print"},{"value":"1687-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}